Abstract

VIRAL VECTOR CORE: Director-J. Johnston The main objective of the Vector Core is to provide DERC center members access to state-of-theart vector technology for preclinical studies. In order to facilitate vector creation and production, the professional staff, using a state-of-the-art facility, will carry out the following: 1) Production of viral vectors derived from adeno-associated viruses (AAV), adenoviruses, and lentiviruses as well as the production of non-viral vectors for use in basic research;2) Work with DERC Investigators to develop vectors or recombinant viruses specifically of use to DERC members;3) Development of gene transfer vectors that will be superior to those of previous generations;4) Submission of the vectors produced to the Bioassay Core to determine the quantity, purity and potency of the vectors produced;5) Development of a web-based database to enable DERC members to request services, monitor the status of vector production, and access historical data on vectors produced by their laboratory.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK019525-35
Application #
8250436
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
35
Fiscal Year
2011
Total Cost
$95,367
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Correnti, Jason M; Gottshall, Lauren; Lin, Annie et al. (2018) Ethanol and C2 ceramide activate fatty acid oxidation in human hepatoma cells. Sci Rep 8:12923
Williams, Bianca; Correnti, Jason; Oranu, Amanke et al. (2018) A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis. FASEB J 32:130-142
Qiu, Chengxiang; Huang, Shizheng; Park, Jihwan et al. (2018) Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease. Nat Med 24:1721-1731
Cohen, Daniel M; Lim, Hee-Woong; Won, Kyoung-Jae et al. (2018) Shared nucleotide flanks confer transcriptional competency to bZip core motifs. Nucleic Acids Res 46:8371-8384
Davila, Antonio; Liu, Ling; Chellappa, Karthikeyani et al. (2018) Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife 7:
Abu-Gazala, Samir; Horwitz, Elad; Ben-Haroush Schyr, Rachel et al. (2018) Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity. Diabetes 67:1079-1085
Zhao, Juanjuan; Lupino, Katherine; Wilkins, Benjamin J et al. (2018) Genomic integration of ERR?-HNF1? regulates renal bioenergetics and prevents chronic kidney disease. Proc Natl Acad Sci U S A 115:E4910-E4919
Pickett-Blakely, Octavia; Young, Kimberly; Carr, Rotonya M (2018) Micronutrients in Nonalcoholic Fatty Liver Disease Pathogenesis. Cell Mol Gastroenterol Hepatol 6:451-462
Kameswaran, Vasumathi; Golson, Maria L; Ramos-Rodríguez, Mireia et al. (2018) The Dysregulation of the DLK1-MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs. Diabetes 67:1807-1815
Huang, Chen; Walker, Emily M; Dadi, Prasanna K et al. (2018) Synaptotagmin 4 Regulates Pancreatic ? Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev Cell 45:347-361.e5

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