Pilot and Feasibility Program The purpose of the Pilot and Feasibility Program (PFP) of the Washington University Diabetes Research Center (DRC) is to provide, on a modest scale: (1) initial support for new investigators who do not yet have their own peer-reviewed research support, (2) support for established investigators from other fields of investigation to apply their expertise to diabetes-related research, and (3) support for established investigators in diabetes embarking on an entirely new direction of research. An important goal of the PFP is to allow these investigators to develop preliminary data sufficient to provide the basis for subsequent applications for independent extramural research support. Following an annual competition, awards of up to $50,000 are made to independent faculty level investigators with the potential for renewal for a second year contingent on demonstrated progress. Grant applicants and recipients are mentored by the PFP Director and DRC Co- Director, Dr. Clay Semenkovich. A total of $250,000 of the annual DRC budget is committed to the PFP, to which substantial institutional support is added. Since 2012, the PFP has supported 35 new projects, 26 of which were awarded to new investigators and 2 of which were awarded to early stage investigators. PFP support during the last funding cycle led to 13 NIH and 4 foundation grants and 49 publications. Thus, the PFP has been a highly productive component of the DRC with an emphasis on mentoring and funding young faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK020579-43
Application #
9851907
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
43
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Abraham, Manjusha; Collins, Christina A; Flewelling, Scott et al. (2018) Mitochondrial inefficiency in infants born to overweight African-American mothers. Int J Obes (Lond) 42:1306-1316
Mikhalkova, Deana; Holman, Sujata R; Jiang, Hui et al. (2018) Bariatric Surgery-Induced Cardiac and Lipidomic Changes in Obesity-Related Heart Failure with Preserved Ejection Fraction. Obesity (Silver Spring) 26:284-290
Yamaguchi, Shintaro; Moseley, Anna C; Almeda-Valdes, Paloma et al. (2018) Diurnal Variation in PDK4 Expression Is Associated With Plasma Free Fatty Acid Availability in People. J Clin Endocrinol Metab 103:1068-1076
Hsu, Fong-Fu (2018) Mass spectrometry-based shotgun lipidomics - a critical review from the technical point of view. Anal Bioanal Chem 410:6387-6409
Chen, Yana; McCommis, Kyle S; Ferguson, Daniel et al. (2018) Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid. Endocrinology 159:609-621
Rusconi, B; Jiang, X; Sidhu, R et al. (2018) Gut Sphingolipid Composition as a Prelude to Necrotizing Enterocolitis. Sci Rep 8:10984
Xu, Wei; Mukherjee, Sumit; Ning, Yu et al. (2018) Cyclopropane fatty acid synthesis affects cell shape and acid resistance in Leishmania mexicana. Int J Parasitol 48:245-256
Zhang, Yan; Rohatgi, Nidhi; Veis, Deborah J et al. (2018) PGC1? Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation. J Bone Miner Res 33:1114-1125
Zhang, Xiangyu; Evans, Trent D; Jeong, Se-Jin et al. (2018) Classical and alternative roles for autophagy in lipid metabolism. Curr Opin Lipidol 29:203-211
Hughes, Jing W; Bao, Yicheng K; Salam, Maamoun et al. (2018) Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease. Diabetes Care :

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