Pilot and Feasibility Program The purpose of the Pilot and Feasibility Program (PFP) of the Washington University Diabetes Research Center (DRC) is to provide, on a modest scale: (1) initial support for new investigators who do not yet have their own peer-reviewed research support, (2) support for established investigators from other fields of investigation to apply their expertise to diabetes-related research, and (3) support for established investigators in diabetes embarking on an entirely new direction of research. An important goal of the PFP is to allow these investigators to develop preliminary data sufficient to provide the basis for subsequent applications for independent extramural research support. Following an annual competition, awards of up to $50,000 are made to independent faculty level investigators with the potential for renewal for a second year contingent on demonstrated progress. Grant applicants and recipients are mentored by the PFP Director and DRC Co- Director, Dr. Clay Semenkovich. A total of $250,000 of the annual DRC budget is committed to the PFP, to which substantial institutional support is added. Since 2012, the PFP has supported 35 new projects, 26 of which were awarded to new investigators and 2 of which were awarded to early stage investigators. PFP support during the last funding cycle led to 13 NIH and 4 foundation grants and 49 publications. Thus, the PFP has been a highly productive component of the DRC with an emphasis on mentoring and funding young faculty.
| Goldner, Nicholas K; Bulow, Christopher; Cho, Kevin et al. (2018) Mechanism of High-Level Daptomycin Resistance in Corynebacterium striatum. mSphere 3: |
| Lin, Jonathan B; Sene, Abdoulaye; Santeford, Andrea et al. (2018) Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging. EBioMedicine 32:9-20 |
| Tuttle, Lori J; Bittel, Daniel C; Bittel, Adam J et al. (2018) Early-Onset Physical Frailty in Adults With Diabesity and Peripheral Neuropathy. Can J Diabetes 42:478-483 |
| Song, Wilbur M; Joshita, Satoru; Zhou, Yingyue et al. (2018) Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism. J Exp Med 215:745-760 |
| Musselman, Laura Palanker; Fink, Jill L; Maier, Ezekiel J et al. (2018) Seven-Up Is a Novel Regulator of Insulin Signaling. Genetics 208:1643-1656 |
| Riek, Amy E; Oh, Jisu; Darwech, Isra et al. (2018) Vitamin D3 supplementation decreases a unique circulating monocyte cholesterol pool in patients with type 2 diabetes. J Steroid Biochem Mol Biol 177:187-192 |
| Peterson, Linda R; Xanthakis, Vanessa; Duncan, Meredith S et al. (2018) Ceramide Remodeling and Risk of Cardiovascular Events and Mortality. J Am Heart Assoc 7: |
| Bittel, Adam J; Bohnert, Kathryn L; Reeds, Dominic N et al. (2018) Reduced Muscle Strength in Barth Syndrome May Be Improved by Resistance Exercise Training: A Pilot Study. JIMD Rep : |
| Hampton, Kaia K; Anderson, Katie; Frazier, Hilaree et al. (2018) Insulin Receptor Plasma Membrane Levels Increased by the Progesterone Receptor Membrane Component 1. Mol Pharmacol 94:665-673 |
| Ferguson, Daniel; Blenden, Mitchell; Hutson, Irina et al. (2018) Mouse Embryonic Fibroblasts Protect ob/ob Mice From Obesity and Metabolic Complications. Endocrinology 159:3275-3286 |
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