The Vanderbilt Diabetes Research and Training Center (VDRTC), in its 43rd continuous year of operation as a NIH-sponsored Diabetes Center, seeks to continue its efforts to facilitate the discovery, application, and translation of scientific knowledge to improve the care of patients with diabetes. The VDRTC is an interdisciplinary program involving 121 participating faculty distributed among 15 departments in two schools and three colleges at Vanderbilt and neighboring Meharry Medical College. The VDRTC consists of: 1) Administrative Component that coordinates the scientific, organizational, and outreach activities; 2) Biomedical Research Component that recruits and selects VDRTC-affiliated investigators and supervises the research cores that facilitate and enhance their research; 3) Pilot and Feasibility Program that facilitates the development of new investigators into independent scientists and encourages scientists in other fields to enter the field of diabetes research; and 4) Enrichment, Training, and Outreach Program that fosters an environment conducive to collaborative, interdisciplinary research (seminar series, Diabetes Research Day), and to training new diabetes scientists. The VDRTC oversees three NIDDK-funded diabetes-related training programs and also serves as the coordinating and organizing center for the NIDDK Medical Student Research Program which has allowed more than 550 medical students from more than 100 US medical schools to conduct diabetes-related research at one of 15 NIH-supported Diabetes Research Centers. NIH support for the VDRTC is greatly amplified by: 1) Vanderbilt's sustained commitment to provide research space and additional financial resources; 2) a diverse, comprehensive array of research core services at Vanderbilt, which allows NIH funds to target unique, diabetes-related research cores; and 3) collaborative efforts with other NIH-funded research centers at Vanderbilt. The VDRTC is evolving and dynamic, including additions to its investigator base, expansion of VDRTC research areas, expanded focus on clinical and translational research, realignment and evolution of core support to provide unique, indispensable core services, and service as a regional and national resource for the diabetes research community. Because of the VDRTC and the environment it creates, VDRTC-affiliated investigators have made important scientific contributions related to diabetes, obesity, and metabolism.

Public Health Relevance

Center Overview: Project Narrative The Vanderbilt Diabetes Research and Training Center is working to understand why diabetes develops, how it can be prevented, and how diabetes treatment can be improved.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK020593-40
Application #
9330507
Study Section
Special Emphasis Panel (ZDK1-GRB-S (J1)P)
Program Officer
Hyde, James F
Project Start
1996-12-01
Project End
2022-03-31
Budget Start
2017-06-16
Budget End
2018-03-31
Support Year
40
Fiscal Year
2017
Total Cost
$1,866,602
Indirect Cost
$522,430
Name
Vanderbilt University Medical Center
Department
Type
Independent Hospitals
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232
Choksi, Yash A; Reddy, Vishruth K; Singh, Kshipra et al. (2018) BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol 11:1363-1374
Zhu, Lin; Luu, Thao; Emfinger, Christopher H et al. (2018) CETP Inhibition Improves HDL Function but Leads to Fatty Liver and Insulin Resistance in CETP-Expressing Transgenic Mice on a High-Fat Diet. Diabetes 67:2494-2506
Shropshire, J Dylan; On, Jungmin; Layton, Emily M et al. (2018) One prophage WO gene rescues cytoplasmic incompatibility in Drosophila melanogaster. Proc Natl Acad Sci U S A 115:4987-4991
Lu, Sichang; McGough, Madison A P; Shiels, Stefanie M et al. (2018) Settable polymer/ceramic composite bone grafts stabilize weight-bearing tibial plateau slot defects and integrate with host bone in an ovine model. Biomaterials 179:29-45
Brissova, Marcela; Haliyur, Rachana; Saunders, Diane et al. (2018) ? Cell Function and Gene Expression Are Compromised in Type 1 Diabetes. Cell Rep 22:2667-2676
Kook, Seunghyi; Qi, Aidong; Wang, Ping et al. (2018) Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes. Am J Respir Cell Mol Biol 58:566-574
Schlegel, Cameron; Weis, Victoria G; Knowles, Byron C et al. (2018) Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease. Dig Dis Sci 63:356-365
Harris, Nicholas A; Isaac, Austin T; Günther, Anne et al. (2018) Dorsal BNST ?2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38:8922-8942
Wilson, Christopher S; Chhabra, Preeti; Marshall, Andrew F et al. (2018) Healthy Donor Polyclonal IgMs Diminish B-Lymphocyte Autoreactivity, Enhance Regulatory T-Cell Generation, and Reverse Type 1 Diabetes in NOD Mice. Diabetes 67:2349-2360
Ehrlicher, Sarah E; Stierwalt, Harrison D; Newsom, Sean A et al. (2018) Skeletal muscle autophagy remains responsive to hyperinsulinemia and hyperglycemia at higher plasma insulin concentrations in insulin-resistant mice. Physiol Rep 6:e13810

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