Abstract

Substantial advances in non-invasive imaging technologies have enabled highly sophisticated assessments of body composition, tissue physiology and brain function that accelerate translational research in human obesity and nutrition. The central goal of the NORC-H Metabolic Imaging Core is to coordinate and centralize the research imaging needs of NORC-H and encourage use of advanced metabolic imaging techniques. The NORC-H Metabolic Imaging Core will also provide support in research design, including but not limited to standard and emerging body composition techniques, positron emission tomography and tracer development, functional magnetic resonance imaging and brain morphology protocols.
The aims of the NORC-H Metabolic Imaging Core are to: 1. Provide a variety of advanced imaging services and assistance in the development of protocols for nutrition and obesity studies in need of imaging-based outcomes. 2. Provide consultative services in imaging analysis, including quantitative interpretation of imaging data. 3. Provide a variety of image-guided biopsy techniques for research purposes, including muscle, liver bone marrow and adipose tissue biopsies. 4. Provide space and technical personnel for specialized imaging analyses. 5. Conduct tutorials and workshops in imaging techniques used in metabolic investigation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK040561-23
Application #
9749152
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2019-08-01
Budget End
2020-07-31
Support Year
23
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114

  Publications

deFilippi, Chris; Lo, Janet; Christenson, Robert et al. (2018) Novel mediators of statin effects on plaque in HIV: a proteomics approach. AIDS 32:867-876
Grinspoon, Steven (2018) NOVEL MECHANISMS AND ANTI-INFLAMMATORY STRATEGIES TO REDUCE CARDIOVASCULAR RISK IN HUMAN IMMUNODEFICIENCY VIRUS. Trans Am Clin Climatol Assoc 129:140-154
Stanford, Fatima Cody; Toth, Alexander T; Shukla, Alpana P et al. (2018) Weight Loss Medications in Older Adults After Bariatric Surgery for Weight Regain or Inadequate Weight Loss: A Multicenter Study. Bariatr Surg Pract Patient Care 13:171-178
De Giuseppe, Rachele; Braschi, Valentina; Bosoni, David et al. (2018) Dietary underreporting in women affected by polycystic ovary syndrome: A pilot study. Nutr Diet :
Foldyna, Borek; Fourman, Lindsay T; Lu, Michael T et al. (2018) Sex Differences in Subclinical Coronary Atherosclerotic Plaque Among Individuals With HIV on Antiretroviral Therapy. J Acquir Immune Defic Syndr 78:421-428
Syed, Sana; Iqbal, Najeeha T; Sadiq, Kamran et al. (2018) Serum anti-flagellin and anti-lipopolysaccharide immunoglobulins as predictors of linear growth faltering in Pakistani infants at risk for environmental enteric dysfunction. PLoS One 13:e0193768
Cheru, Lediya T; Fitch, Kathleen V; Saylor, Charles F et al. (2018) Mild renal impairment is associated with calcified plaque parameters assessed by CT angiography in people living with HIV. AIDS :
Xu, He; Lee, Min-Sik; Tsai, Pei-Yun et al. (2018) Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis. Proc Natl Acad Sci U S A 115:4228-4233
Jacobson, Sandra W; Carter, R Colin; Molteno, Christopher D et al. (2018) Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Alcohol Clin Exp Res 42:1327-1341
Benson, Mark D; Yang, Qiong; Ngo, Debby et al. (2018) Genetic Architecture of the Cardiovascular Risk Proteome. Circulation 137:1158-1172

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