application) This is an application for a 5-year renewal for the Colorado Clinical Nutrition Research Unit (CNRU). The Colorado CNRU was originally funded in January 1995 to serve 41 investigators with 5 million dollars in funding for nutrition-related research. Now, if our fourth year of operation, we serve 56 investigators with approximately 10 million dollars in nutrition-related funding. The broad goal of the Colorado CNRU is to enhance the nutrition-related research of our research base and to help promising young scientists with an interest in nutrition develop into independent investigators. The theme of the Colorado CNRU, nutrient utilization, captures the broad interests of a majority of our research base members. We have identified 4 research focus areas within that broad theme: obesity and diabetes; developmental aspects of nutrient utilization; micronutrient utilization and function, and community nutrition. The research supported by the CNRU includes a continuum from the patient or healthy subject to the subcellular and molecular levels. We propose an Administrative Core and 3 scientific core laboratories: Energy Balance, Metabolic, and Mass Spectrometry. The use of core laboratories, the number of CNRU supported publications and the federal funding for nutrition research has grown steadily over our first 4 years of operation. The CNRU Director, Dr. James O. Hill and the Associate Director, Dr. Robert H. Eckel are supported by a strong Executive Committee. The Colorado CNRU is located with an exciting Center for Human Nutrition at the University of Colorado Health Sciences Center, but faculty from Colorado State University participate in the CNRU through an existing CU-CSU consortium. The Center for Human Nutrition has strong programs for nutrition education, research training, clinical nutrition services and community outreach. The existence of a CNRU in Colorado has energized an already strong group of nutrition investigators and has led to many exciting new collaborations and interactions. Through the CNRU, our nutrition investigators have gained recognition both nationally and within our universities. We look forward to continuing to enhance nutrition research within Colorado over the next 5 years.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK048520-08
Application #
6489683
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (M1))
Program Officer
Hubbard, Van S
Project Start
1995-03-15
Project End
2004-12-31
Budget Start
2002-01-01
Budget End
2002-12-31
Support Year
8
Fiscal Year
2002
Total Cost
$970,315
Indirect Cost
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Rozance, Paul J; Zastoupil, Laura; Wesolowski, Stephanie R et al. (2018) Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol 596:67-82
Abbate, Lauren M; Jeffreys, Amy S; Coffman, Cynthia J et al. (2018) Demographic and Clinical Factors Associated With Nonsurgical Osteoarthritis Treatment Among Patients in Outpatient Clinics. Arthritis Care Res (Hoboken) 70:1141-1149
Montasser, May E; O'Hare, Elizabeth A; Wang, Xiaochun et al. (2018) An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels. Circulation 138:1343-1355
Rudolph, Michael C; Jackman, Matthew R; Presby, David M et al. (2018) Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance. Diabetes 67:651-661
Gregory, Mark A; Nemkov, Travis; Reisz, Julie A et al. (2018) Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol 58:52-58
Cara-Fuentes, Gabriel; Lanaspa, Miguel A; Garcia, Gabriela E et al. (2018) Urinary CD80: a biomarker for a favorable response to corticosteroids in minimal change disease. Pediatr Nephrol 33:1101-1103
Ostendorf, Danielle M; Lyden, Kate; Pan, Zhaoxing et al. (2018) Objectively Measured Physical Activity and Sedentary Behavior in Successful Weight Loss Maintainers. Obesity (Silver Spring) 26:53-60
Bruce, Kimberley D; Gorkhali, Sachi; Given, Katherine et al. (2018) Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci 11:57
Allshouse, Amanda A; Santoro, Nanette; Green, Robin et al. (2018) Religiosity and faith in relation to time to metabolic syndrome for Hispanic women in a multiethnic cohort of women-Findings from the Study of Women's Health Across the Nation (SWAN). Maturitas 112:18-23
Gavin, Kathleen M; Kohrt, Wendy M; Klemm, Dwight J et al. (2018) Modulation of Energy Expenditure by Estrogens and Exercise in Women. Exerc Sport Sci Rev 46:232-239

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