This is renewal application for an interdepartmental training program in Infectious Diseases and Inflammatory Disorders. It is designed to foster the interests of outstanding medical students in biomedical research. In the current funding periods (2014-2019), this program has offered training opportunities for a total of 47 trainees, leading to publication/submission of 14 peer-reviewed manuscripts and 19 poster awards at national/regional scientific meetings. Importantly, this enrichment program combines the faculty?s innovative research expertise with unique institutional strengths for the education of medical students. Hands-on training will be provided by 23 faculty members from seven basic science and clinical departments at UTMB. The research themes will be centered on infections and inflammation, especially on transmission of pathogens, the pathogenesis of neuroinflammation, regulation of host inflammatory responses at the sites of pathogen entry (airway, skin, and mucosa), regulation of leukocyte migration in the blood, liver brain and other organs, and vaccine/drug development for the control of pathogens and tissue damage. Trainees (9 per year, 45 in total) will devote full- time participation during a ten-week research period and will gain an in-depth knowledge of biological concepts, modern research areas and tools. They will have the opportunity to choose basic, clinical, translational, or behavior research projects. The program will match talented medical students with NIH-funded faculty mentors, coupling the daily experience with an ongoing series of courses, summer research seminars, research-in-progress discussions, oral presentations, and monitoring from faculty members. The specific objectives are 1) to expose medical students early in their career to the excitement and technology of medical research and to foster their investigative and analytical skills; 2) to encourage medical students to pursue a career in basic and clinical research in the areas of infectious diseases and inflammatory disorders; and 3) to provide valuable experience and references for students who wish to seek additional research training and funding in the future. An adequate tracking system is in place for monitoring the career development of trainees and the continued success of this training program. Our ultimate goal is to promote the professional development for our medical students, enhancing their skills in research, oral/written presentations and leaderships.

Public Health Relevance

This program will provide short-term, hands-on training for medical students in the area of infectious diseases and inflammatory disorders. It is designed to foster the interests of outstanding medical students in biomedical research and has successful outcomes in the past ten years of funding period.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
NRSA Short -Term Research Training (T35)
Project #
2T35AI078878-11
Application #
10090094
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Gondre-Lewis, Timothy A
Project Start
2008-06-01
Project End
2026-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
11
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Texas Med Br Galveston
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
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Liang, Yuejin; Yi, Panpan; Yuan, Denley Ming Kee et al. (2018) IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis. Cell Mol Immunol :
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Liang, Yuejin; Jie, Zuliang; Hou, Lifei et al. (2015) IL-33 promotes innate IFN-? production and modulates dendritic cell response in LCMV-induced hepatitis in mice. Eur J Immunol 45:3052-63
Gupta, Shivali; Silva, Trevor S; Osizugbo, Jessica E et al. (2014) Serum-mediated activation of macrophages reflects TcVac2 vaccine efficacy against Chagas disease. Infect Immun 82:1382-9
Gupta, Shivali; Wan, Xianxiu; Zago, Maria P et al. (2013) Antigenicity and diagnostic potential of vaccine candidates in human Chagas disease. PLoS Negl Trop Dis 7:e2018

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