ARAC The overarching mission of the WU-DDRCC is to promote collaborative, multidisciplinary research focused on interactions between host and environment in digestive disease. The goals of the Administrative and Resource Access Core (ARAC) are to coordinate, manage and integrate all activities of the WU-DDRCC, thereby maximizing value to our membership from all Cores and Enrichment Programs. These goals will be accomplished by: (1) Aligning Core services and technologies to reflect thematic interests of our Research Base; (2) Promoting multidisciplinary, collaborative research in digestive disease through an Enrichment Program of regular seminars, visiting speakers, journal clubs, symposia and mini-sabbaticals; (3) Nurturing junior faculty career development via Pilot and Feasibility (P/F) Awards that facilitate scientific independence: (4) Catalyzing collaborative and synergistic interaction among other NIDDK funded Centers locally (DRC, NORC) and other DDRCCs throughout the region (Midwest Alliance). The ARAC pursues these goals by providing stable, responsive stewardship of scientific Cores, global financial oversight and strategic allocation of supplemental awards to leverage institutional Cores. These goals are guided by both Internal (IAB), and External Advisory Boards (EAB). KEY ACCOMPLISHMENTS since 2013 include: (1) Alignment of membership reflecting evolving interests and departures balanced with new recruitment (50 Full members 12/2018 vs 49 Full members 12/2013), with 50% of the current membership new since 2013, (2) Support of membership realized through 30% net growth in Annual Direct Costs (ADC) ($23.8M 12/2013 vs $30.9M 12/2018). (3) Evolution of Core services in response to new institutional investment, most notably a new Precision Animal Models and Organoids Core (PAMOC), (4) Investing in P/F Awardees, resulting in a 26:1 return on investment since 2013 and launching academic careers in research (95% still active in digestive disease research among awardees from 1999 to present), (5) Sponsoring an Enrichment Program featuring ~12 external speakers/year (including at least one designated underrepresented minority/year), a formal mentorship program THE SPECIFIC AIMS FOR THE ARAC ARE: (1) Provide leadership, governance and administrative infrastructure for members, including strategic alignment of Core services with current and future needs of the Research Base. (2) Manage and oversee Core services to assure timely, high quality, specialized expertise, guided by an Internal Executive Committee (IEC) and an Internal Advisory Board (IAB). (3) Review Research Base membership and align thematic interests, guided by IEC and Thematic Program Leaders. (4) Promote scientific independence for junior faculty through a P/F Program guided by an External Advisory Board (EAB) who review and select Awardees. (5) Promote collaboration, awareness of new scientific initiatives, career development and diversity through a dynamic Enrichment Program. (6) Assure continued administrative and scientific dialog with other DDRCCs particularly those in the Midwest Alliance as well as the NIDDK DDRCC program website.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK052574-21
Application #
9888918
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
21
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Engelstad, Holly J; Barron, Lauren; Moen, Joseph et al. (2018) Remnant Small Bowel Length in Pediatric Short Bowel Syndrome and the Correlation with Intestinal Dysbiosis and Linear Growth. J Am Coll Surg 227:439-449
Rusconi, B; Jiang, X; Sidhu, R et al. (2018) Gut Sphingolipid Composition as a Prelude to Necrotizing Enterocolitis. Sci Rep 8:10984
Knoop, Kathryn A; Newberry, Rodney D (2018) Goblet cells: multifaceted players in immunity at mucosal surfaces. Mucosal Immunol 11:1551-1557
Choi, Jaebok; Cooper, Matthew L; Staser, Karl et al. (2018) Baricitinib-induced blockade of interferon gamma receptor and interleukin-6 receptor for the prevention and treatment of graft-versus-host disease. Leukemia 32:2483-2494
Mills, Jason C; Samuelson, Linda C (2018) Past Questions and Current Understanding About Gastric Cancer. Gastroenterology 155:939-944
Vishy, Courtney E; Swietlicki, Elzbieta A; Gazit, Vered et al. (2018) Epimorphin regulates the intestinal stem cell niche via effects on the stromal microenvironment. Am J Physiol Gastrointest Liver Physiol 315:G185-G194
Brown, Jeffrey W; Badahdah, Arwa; Iticovici, Micah et al. (2018) A Role for Salivary Peptides in the Innate Defense Against Enterotoxigenic Escherichia coli. J Infect Dis 217:1435-1441
Wilen, Craig B; Lee, Sanghyun; Hsieh, Leon L et al. (2018) Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science 360:204-208
Ingle, Harshad; Peterson, Stefan T; Baldridge, Megan T (2018) Distinct Effects of Type I and III Interferons on Enteric Viruses. Viruses 10:
Wang, Xuanchuan; Xu, Min; Jia, Jianluo et al. (2018) CD47 blockade reduces ischemia/reperfusion injury in donation after cardiac death rat kidney transplantation. Am J Transplant 18:843-854

Showing the most recent 10 out of 899 publications