The Pilot and Feasibility Program is a critical component of the Baltimore PKD Center (B-PKD Center).
The Specific Aims of the Pilot and Feasibility Program are: 1) To stimulate and solicit high quality research proposals related to the B-PKD Center themes 2) To encourage submission of pilot projects by junior investigators 3) To review pilot proposals for their innovativeness and scientific merit 4) To provide mentorship to junior investigators receiving P & F awards in order to maximize the chance of career success and 5) To record the career events (ie publications, grants, honors etc) of Pilot Project awardees. Dr. Terry Watnick, the Baltimore PKD Center Director, will manage the Pilot and Feasibility Program. She will be responsible for recruiting proposals and for assigning each application to two qualified reviewers, one who will be external to the B-PKD Center. We anticipate that two meritorious proposals will be funded each year with additional proposals funded at the University of Maryland through the Dean's office in Years 2-4. Pilot studies chosen for year 1 are tightly focused around Core Resources and recruit two new investigators with unique areas of expertise to the study of polycystic kidney disease. Pilot 1 will focus on ciliary signaling in cardiac myocytes and will also investigate the role of polycystin-2 in this cell type. Pilot 2 stems from the observation that ADPKD is associated with the occurrence of supernumerary centrioles. This proposal will use unique animal models to test the hypothesis that that centriole amplification may promote renal cyst formation. In summary, the Pilot and Feasibility Program will continue to be instrumental in encouraging new investigators to join the PKD field, in developing new research directions and in attracting diverse talent to the study of polycystic kidney disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK090868-07
Application #
8973864
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M5))
Project Start
Project End
Budget Start
2015-09-25
Budget End
2016-06-30
Support Year
7
Fiscal Year
2015
Total Cost
$168,866
Indirect Cost
$59,213
Name
University of Maryland Baltimore
Department
Type
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
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Bulley, Simon; Fernández-Peña, Carlos; Hasan, Raquibul et al. (2018) Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure. Elife 7:
Cai, Jing; Song, Xuewen; Wang, Wei et al. (2018) A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease. Genes Dev 32:781-793
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Lin, Cheng-Chao; Kurashige, Mahiro; Liu, Yi et al. (2018) A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed. Sci Rep 8:2743
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Podrini, Christine; Rowe, Isaline; Pagliarini, Roberto et al. (2018) Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways. Commun Biol 1:194
Palygin, Oleg; Ilatovskaya, Daria V; Levchenko, Vladislav et al. (2018) Characterization of purinergic receptor expression in ARPKD cystic epithelia. Purinergic Signal 14:485-497
Dalagiorgou, Georgia; Piperi, Christina; Adamopoulos, Christos et al. (2017) Mechanosensor polycystin-1 potentiates differentiation of human osteoblastic cells by upregulating Runx2 expression via induction of JAK2/STAT3 signaling axis. Cell Mol Life Sci 74:921-936
Kleene, Steven J; Kleene, Nancy K (2017) The native TRPP2-dependent channel of murine renal primary cilia. Am J Physiol Renal Physiol 312:F96-F108

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