The proposed UCSF NORC will integrate multiple research programs in multiple areas of nutrition, obesity and metabolism. Over the last twelve years, UCSF has actively expanded its research base in this critical subject area. Today, that research base is very robust but with an administrative and facilities infrastructure that reflects the diversity of the departmental processes that expanded this program. The proposed NORC will provide a cohesive programmatic, administrative and shared facilities infrastructure that will integrate the already strong nutrition, obesity and metabolism research conducted at UCSF and that will provide a framework for its coordinated growth. The UCSF NORC will include cellular, animal, translational, clinical and epidemiologic directions. Despite this breath, these programs are highly interactive with extensive collaborations amongst even the most divergent of programs. For example, radiologists collaborate with clinical scientists to non-invasively visualize metabolism in humans. Human geneticists collaborate with cellular and animal researchers to investigate hypotheses more tractable in those systems. Behavioral scientists coordinate with nutritionists to search for ways to improve outcomes. In all, the 44 interdisciplinary investigators within the UCSF-NORC will consist of a mixture of senior and early stage investigators with a collective 60 NIH grants (100 grants total). Their collective goal will be to define the underlying mechanisms of disease and to significantly contribute to the prevention and treatment of obesity and its complications. The purpose of the UCSF-NORC will be to promote and grow research in obesity, nutrition, and metabolism at UCSF and throughout northern California. This will be realized by: Maintaining, improving, and promoting the interactions and collaborations of researchers in the field with each other and with those outside the field. Supporting the maintenance and evolution of state-of-the-art Research Cores to meet the needs of obesity, nutrition, and metabolism research. Facilitating the development of new research directions and the entry of new researchers into the field via Pilot & Feasibility opportunities. Enriching the NORC research community through pertinent educational forums and other venues that support the development and maintenance of research interactions. Integrating administrative support to ensure that the infrastructure meets the needs of the local obesity, nutrition and metabolism research community.
The proposed UCSF-NORC will be a highly integrated community of researchers spanning the spectrum from basic research through to the clinical implementation of new treatments. To achieve that, the NORC will supply, coordinate and oversee facilities and programs that bring the researchers together. Once implemented, the NORC is projected to increase the cohesiveness, and enhance the visibility, of the already strong nutrition, obesity and metabolism research at UCSF and thereby enable the development of outstanding, cutting-edge and multi-disciplinary studies.
|Kjaer, T W; Faurholt-Jepsen, D; Mehta, K M et al. (2018) Shorter preschool, leukocyte telomere length is associated with obesity at age 9 in Latino children. Clin Obes 8:88-94|
|Alba, Diana L; Farooq, Jeffrey A; Lin, Matthew Y C et al. (2018) Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans. J Clin Endocrinol Metab 103:3194-3204|
|Kazakia, Galateia J; Carballido-Gamio, Julio; Lai, Andrew et al. (2018) Trabecular bone microstructure is impaired in the proximal femur of human immunodeficiency virus-infected men with normal bone mineral density. Quant Imaging Med Surg 8:5-13|
|Masand, Ruchi; Paulo, Esther; Wu, Dongmei et al. (2018) Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. Cell Metab 27:616-629.e4|
|Cummings, Jenna R; Mason, Ashley E; Puterman, Eli et al. (2018) Comfort Eating and All-Cause Mortality in the US Health and Retirement Study. Int J Behav Med 25:473-478|
|Mason, Ashley E; Schleicher, Samantha; Coccia, Michael et al. (2018) Chronic Stress and Impulsive Risk-Taking Predict Increases in Visceral Fat over 18 Months. Obesity (Silver Spring) 26:869-876|
|Jin, Yichen; DiPietro, Loretta; Kandula, Namratha R et al. (2018) Associations Between Television Viewing and Adiposity Among South Asians. J Racial Ethn Health Disparities 5:1059-1062|
|McQueen, Allison E; Koliwad, Suneil K; Wang, Jen-Chywan (2018) Fighting obesity by targeting factors regulating beige adipocytes. Curr Opin Clin Nutr Metab Care 21:437-443|
|Tharp, Kevin M; Kang, Michael S; Timblin, Greg A et al. (2018) Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues. Cell Metab 27:602-615.e4|
|Mehta, Anurag; Patel, Jaideep; Al Rifai, Mahmoud et al. (2018) Inflammation and coronary artery calcification in South Asians: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Atherosclerosis 270:49-56|
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