The overall aim of this core is to evaluate mechanisms of oxidative injury, inflammation and repair in both the respiratory and cardiovascular systems caused by environmental and occupational agents.
This aim has been a central focus for the core since the 1940?s when Rochester first began investigation into the pulmonary toxicology of airborne particulates. Focus today continues not only on airborne particulates, but also on oxidant gases, endotoxin, siloxanes, zinc oxide and ionizing radiation. Experimental approaches range from basic cellular and molecular methods to animal and clinical human studies. The core studies the impact of inhaled agents in asthma, COPD, fibrosis and lung cancer. Factors that modulate the toxicological effects of inhaled agents, such as age and underlying disease, are also studied. A new approach that has evolved over the last 5 years is the focus on systemic effects of inhaled agents, in particular effects on the cardiovascular system. Nearly 50% of the 181 publications cited since the last renewal are joint authored by members of the core, speaking to the intense collaborative effort underway. The studies carried out by core members result in publications in strong, high-impact scientific journals (AJP Lung, AJRCCM, Environ Health Perspectives, J Immunol, Inhalation Toxicol). All members are now housed under one roof with the construction of a new research building, enhancing the collaborative effort.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES001247-31
Application #
6867267
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2005-04-01
Project End
2010-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
31
Fiscal Year
2005
Total Cost
$59,634
Indirect Cost
Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Begolly, Sage; Olschowka, John A; Love, Tanzy et al. (2018) Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion. Glia 66:846-861
Korfmacher, Katrina Smith; Holt, Kathleen D (2018) The Potential for Proactive Housing Inspections to Inform Public Health Interventions. J Public Health Manag Pract 24:444-447
Wong, Elissa L; Lutz, Nina M; Hogan, Victoria A et al. (2018) Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex. Brain Behav Immun 67:257-278
Barrett, Emily S; Vitek, Wendy; Mbowe, Omar et al. (2018) Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility. Hum Reprod 33:1757-1766
Franchini, Anthony M; Lawrence, B Paige (2018) Environmental exposures are hidden modifiers of anti-viral immunity. Curr Opin Toxicol 10:54-59
van den Dries, Michiel A; Pronk, Anjoeka; Guxens, Mònica et al. (2018) Determinants of organophosphate pesticide exposure in pregnant women: A population-based cohort study in the Netherlands. Int J Hyg Environ Health 221:489-501
Beach, Tyler A; Groves, Angela M; Johnston, Carl J et al. (2018) Recurrent DNA damage is associated with persistent injury in progressive radiation-induced pulmonary fibrosis. Int J Radiat Biol 94:1104-1115
Morris-Schaffer, Keith; Sobolewski, Marissa; Welle, Kevin et al. (2018) Cognitive flexibility deficits in male mice exposed to neonatal hyperoxia followed by concentrated ambient ultrafine particles. Neurotoxicol Teratol 70:51-59
Santos, Susana; Eekhout, Iris; Voerman, Ellis et al. (2018) Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania. BMC Med 16:201
Huang, Li-Shan; Cory-Slechta, Deborah A; Cox, Christopher et al. (2018) Analysis of Nonlinear Associations between Prenatal Methylmercury Exposure from Fish Consumption and Neurodevelopmental Outcomes in the Seychelles Main Cohort at 17 Years. Stoch Environ Res Risk Assess 32:893-904

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