(Overall Component) The overarching goals of our Environmental Health Sciences Center (EHSC) are to prevent disease and improve public health through innovative programs of excellence in environmental health sciences research, to engage communities to address environmental health issues, and to enhance career development of talented environmental health investigators. The EHSC provides the framework for the generation of novel research findings and their conversion into effective resources for public health officials, medical professionals, and the community. This tradition of success is based on our ability to recruit broad multi- and interdisciplinary expertise, maintain a strong emphasis on basic science principles while incorporating clinical and translational approaches, and effectively interact with the community. The specific mission of the EHSC at Rochester is to improve public health through the generation of fundamental knowledge and elaboration of mechanisms by which chemical exposures, alone or through interaction with other modifying factors, contribute to cumulative health risk across the life span. As such, the theme that guides and integrates EHSC research and community engagement programs is the understanding of interactions of environmental and occupational agents with diverse individual contexts across the lifespan in modulating human disease and dysfunction. The goals of the Center are achieved through a major focus on three research programs: Pulmonary & Cardiovascular Disease Program, Neurodevelopmental & Neurodegenerative Disease Program, and Musculoskeletal Disease Program. While the Center is structurally organized into these Disease Programs, shared thematic biological processes, including immunological responses & inflammation, stem cell biology, early life sensitivities and mechanisms of adult disease, epigenetics, and nutritional/dietary factors, weave these programs together and synergize the research. These research efforts are supported by several structural units: Administrative Core, Integrative Health Sciences Facility Core, Biostatistics Facility Core, Community Outreach & Engagement Core, Pilot Project Program, and Career Development Program for Environmental Health Science Investigators.

Public Health Relevance

The mission of the EHSC at Rochester is to improve public health through the generation of fundamental knowledge and elaboration of mechanisms by which chemical exposures, alone or through interaction with other modifying factors, contribute to cumulative health risk across the lifespan. This mission is achieved by the integration of basic science with clinical research, and the translation of this research through community engagement, education and prevention. The EHSC provides the framework for the generation of novel research findings and their conversion into effective resources for public health officials, medical professionals, and the community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES001247-43
Application #
9249583
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
43
Fiscal Year
2017
Total Cost
$153,500
Indirect Cost
$53,500
Name
University of Rochester
Department
Type
Domestic Higher Education
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Cholette, Jill M; Pietropaoli, Anthony P; Henrichs, Kelly F et al. (2018) Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures, and altered inflammatory markers in pediatric cardiac surgery patients. Transfusion 58:1631-1639
Boule, Lisbeth A; Burke, Catherine G; Jin, Guang-Bi et al. (2018) Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome. Sci Rep 8:1826
Lacy, Shannon H; Woeller, Collynn F; Thatcher, Thomas H et al. (2018) Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Anti-Fibrotic Prostaglandins. Am J Respir Cell Mol Biol :
Lacy, Shannon H; Epa, Amali P; Pollock, Stephen J et al. (2018) Activated human T lymphocytes inhibit TGF?-induced fibroblast to myofibroblast differentiation via prostaglandins D2 and E2. Am J Physiol Lung Cell Mol Physiol 314:L569-L582
Sobolewski, Marissa; Singh, Garima; Schneider, Jay S et al. (2018) Different Behavioral Experiences Produce Distinctive Parallel Changes in, and Correlate With, Frontal Cortex and Hippocampal Global Post-translational Histone Levels. Front Integr Neurosci 12:29
Caito, Samuel W; Jackson, Brian P; Punshon, Tracy et al. (2018) Editor's Highlight: Variation in Methylmercury Metabolism and Elimination Status in Humans Following Fish Consumption. Toxicol Sci 161:443-453
Begolly, Sage; Olschowka, John A; Love, Tanzy et al. (2018) Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion. Glia 66:846-861
Korfmacher, Katrina Smith; Holt, Kathleen D (2018) The Potential for Proactive Housing Inspections to Inform Public Health Interventions. J Public Health Manag Pract 24:444-447
Wong, Elissa L; Lutz, Nina M; Hogan, Victoria A et al. (2018) Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex. Brain Behav Immun 67:257-278
Barrett, Emily S; Vitek, Wendy; Mbowe, Omar et al. (2018) Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility. Hum Reprod 33:1757-1766

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