Abstract

The Exposure and Dosimetry Modeling Facility Core is directed by Dr. Georgopoulos. Workstations and server clusters that service this facility are located within the EOHSI and the hardware and software used are facilities of the EOHSI Computational Chemodynamics Laboratory (CCL).
The aims of this core are to adapt, improve, and test methods for (1) estimating toxic exposures, including pharmacokinetic modeling of target tissue exposure, (2) assessing biomarkers of exposure, and (3) estimating transport, concentration, and deposition of chemicals, including estimation of inter- and intra-individual variation. The support services offered are (1) assistance with data analysis and (2) assistance with computer modeling. The only tangible evidence of past performance of this Core is contained in four examples, which are critiqued below. Future directions are slated for continued efforts in developing distributed parameter models, and new efforts to incorporate random effects modeling and create food-web models.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
3P30ES005022-15S1
Application #
6587355
Study Section
Project Start
2002-04-15
Project End
2003-03-31
Budget Start
Budget End
Support Year
15
Fiscal Year
2002
Total Cost
$174,086
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Type
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854

  Publications

Sagona, Jessica A; Weisel, Clifford; Meng, Qingyu (2018) Accuracy and practicality of a portable ozone monitor for personal exposure estimates. Atmos Environ (1994) 175:120-126
Mauro, T; Hao, L; Pop, L C et al. (2018) Circulating zearalenone and its metabolites differ in women due to body mass index and food intake. Food Chem Toxicol 116:227-232
Fournier, S B; D'Errico, J N; Stapleton, P A (2018) Engineered nanomaterial applications in perinatal therapeutics. Pharmacol Res 130:36-43
Stapleton, P A; Hathaway, Q A; Nichols, C E et al. (2018) Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome. Part Fibre Toxicol 15:3
Fiedler, Nancy; Weisel, Clifford; Nwankwo, Chizoba et al. (2018) Chronic Exposure to Solvents Among Construction Painters: Reductions in Exposure and Neurobehavioral Health Effects. J Occup Environ Med 60:e663-e670
Therkorn, Jennifer; Calderon, Leonardo; Cartledge, Benton et al. (2018) Inactivation of Pure Bacterial Biofilms by Impaction of Aerosolized Consumer Products Containing Nanoparticulate Metals. Environ Sci Nano 5:544-555
Lee, Heedoo; Zhang, Duo; Laskin, Debra L et al. (2018) Functional Evidence of Pulmonary Extracellular Vesicles in Infectious and Noninfectious Lung Inflammation. J Immunol 201:1500-1509
Del Giudice, Marco; Barrett, Emily S; Belsky, Jay et al. (2018) Individual differences in developmental plasticity: A role for early androgens? Psychoneuroendocrinology 90:165-173
Barrett, E S; Hoeger, K M; Sathyanarayana, S et al. (2018) Anogenital distance in newborn daughters of women with polycystic ovary syndrome indicates fetal testosterone exposure. J Dev Orig Health Dis 9:307-314
George, Blessy; Joy, Melanie S; Aleksunes, Lauren M (2018) Urinary protein biomarkers of kidney injury in patients receiving cisplatin chemotherapy. Exp Biol Med (Maywood) 243:272-282

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