Abstract

Resources and Facilities - Bioinformatics Module Bioinformatics server. We have set up a web and ftp server for researchers to exchange large scale data sets, and another bioinformatics server to store and process microarray data sets. Both systems are based on Red Hat Linux. We are also in charge of maintaining a server to automatically backup all data from tens of workstation of faculties, postdocs, students and technicians in the Wilmer. Bioinformatics workstation. We have 5 Dell Precision 690 Workstations with Xeon 3G Hz CPU, 4G memory, 500 G Disk storage, 19-in flat panel display, and facilities for a rewritable DVD. The workstations run Microsoft Windows 7/Vista/XP and Red Hat Linux. Bioinformatics software and databases. We utilize both public-access and commercial bioinformatics software (including ImagaGene, VectorNTI, GeneSight, almaZen, GeneTraffic, Partek). We also subscribe the update of professional version of the transcription factor database TRANSFAC. In some cases, we utilized publicly available packages such as R-Bioconductor then organized the results based on our collaborators' requests. Sometimes, we wrote our own codes in R, Matlab, Perl, etc. to customize the programs for individual needs of our researchers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001765-40
Application #
8910711
Study Section
Special Emphasis Panel (ZEY1-VSN)
Project Start
Project End
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
40
Fiscal Year
2015
Total Cost
$209,438
Indirect Cost
$80,155

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205

  Publications

Park, Tea Soon; Zimmerlin, Ludovic; Evans-Moses, Rebecca et al. (2018) Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency. J Vis Exp :
Hinkle, Jared T; Perepezko, Kate; Bakker, Catherine C et al. (2018) Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis. Int J Geriatr Psychiatry 33:e131-e139
Duncan, Gregg A; Kim, Namho; Colon-Cortes, Yanerys et al. (2018) An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy. Mol Ther Methods Clin Dev 9:296-304
Long, Da; Kanan, Yogita; Shen, Jikui et al. (2018) VEGF/VEGFR2 blockade does not cause retinal atrophy in AMD-relevant models. JCI Insight 3:
Liu, Melissa M; Cho, Chris; Jefferys, Joan L et al. (2018) Use of Optical Coherence Tomography by Nonexpert Personnel as a Screening Approach for Glaucoma. J Glaucoma 27:64-70
Ebrahimi, Katayoon B; Cano, Marisol; Rhee, John et al. (2018) Oxidative Stress Induces an Interactive Decline in Wnt and Nrf2 Signaling in Degenerating Retinal Pigment Epithelium. Antioxid Redox Signal 29:389-407
Pitha, Ian; Kimball, Elizabeth C; Oglesby, Ericka N et al. (2018) Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOP-Glaucoma. Transl Vis Sci Technol 7:13
Sharma, Anjali; Porterfield, Joshua E; Smith, Elizabeth et al. (2018) Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model. J Control Release 283:175-189
Kimball, Elizabeth C; Jefferys, Joan L; Pease, Mary E et al. (2018) The effects of age on mitochondria, axonal transport, and axonal degeneration after chronic IOP elevation using a murine ocular explant model. Exp Eye Res 172:78-85
Nesper, Peter L; Lutty, Gerard A; Fawzi, Amani A (2018) RESIDUAL CHOROIDAL VESSELS IN ATROPHY CAN MASQUERADE AS CHOROIDAL NEOVASCULARIZATION ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Introducing a Clinical and Software Approach. Retina 38:1289-1300

Showing the most recent 10 out of 851 publications