The Massachusetts Eye and Ear Infirmary (MEEI) is an internationally-recognized leading institution for academic ophthalmology and vision research. MEEI is the primary institution for the Department of Ophthalmology at Harvard Medical School, one of the largest academic departments of Ophthalmology world-wide. The overall purpose of this P30 Center Core Grant for Vision Research is to enhance the research capabilities at the Massachusetts Eye and Ear Infirmary (MEEI) by providing resources that would not otherwise be available to investigators who are PIs of NEl-funded ROIs. The Core resources has increased research productivity, supported collaborative research, supported young investigators and have contributed to successful faculty recruitment. Through collaboration with MEEI vision scientists new faculty have been attracted to vision research. This P30 competing renewal requests funds to support three resource cores: Genomics, (Eric Pierce director), will provide access to state-of-the-art genomic resources;BioBank, (Janey Wiggs, director) will support the collection of patient-related samples and provide support for linking patient material with genomic and clinical data;and Biostatistics (Louis Pasquale, director) will provide resources and support for a variety of statistical analyses including geneti associations, power calculations and analysis of gene expression data. These resources form the basis of an integrated research plan that enhances the research capabilities at MEEI and in particular supports translation of basic science discoveries to clinically relevant information. Four general research themes are supported by this research plan: Genetics and genomics of ocular disease, identification of risk factors for common complex ocular disease, defining the molecular basis of ocular infection and antibiotic-resistant infections, and the cell and molecular biology of neuro-degenerative conditions affecting the eye. The overarching goals are to define the risk factors and molecular events contributing to blinding eye disease as the initial steps toward the development of novel disease-based diagnostic and therapeutic modalities with the ultimate goal of promoting personalized medicine for ocular disorders.

Public Health Relevance

This P30 Center Core Grant for Vision Research provides critically important resources that support the overall research program at the Massachusetts Eye and Ear Infirmary, and in particular supports the translation of new knowledge into clinical information that positively impacts the diagnosis and care of patients affected by blinding visual disorders.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY014104-11
Application #
8745019
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
2002-04-01
Project End
2019-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts Eye and Ear Infirmary
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02114
Jamshidi, Farzad; Place, Emily M; Mehrotra, Sudeep et al. (2018) Contribution of noncoding pathogenic variants to RPGRIP1-mediated inherited retinal degeneration. Genet Med :
Lee, Jeong Yoon; Lee, Ji Sun; Materne, Emma C et al. (2018) Bacterial RecA Protein Promotes Adenoviral Recombination during In Vitro Infection. mSphere 3:
Kosmidou, Cassandra; Efstathiou, Nikolaos E; Hoang, Mien V et al. (2018) Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Sci Rep 8:461
Ismail, Ashrafali M; Lee, Ji Sun; Lee, Jeong Yoon et al. (2018) Adenoviromics: Mining the Human Adenovirus Species D Genome. Front Microbiol 9:2178
Bauer, Corinna M; Cattaneo, Zaira; Merabet, Lotfi B (2018) Early blindness is associated with increased volume of the uncinate fasciculus. Eur J Neurosci 47:427-432
Bailey, Jessica N Cooke; Gharahkhani, Puya; Kang, Jae H et al. (2018) Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets. Invest Ophthalmol Vis Sci 59:629-636
Fernandez-Godino, Rosario; Bujakowska, Kinga M; Pierce, Eric A (2018) Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway. Hum Mol Genet 27:147-159
Ismail, Ashrafali M; Cui, Tiange; Dommaraju, Kalpana et al. (2018) Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens. Emerg Microbes Infect 7:10
Choi, Hee Joo; Wang, Rui; Jakobs, Tatjana C (2018) Single-Cell Dissociation and Characterization in the Murine Retina and Optic Nerve. Methods Mol Biol 1695:311-334
Paschalis, Eleftherios I; Lei, Fengyang; Zhou, Chengxin et al. (2018) Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes. Proc Natl Acad Sci U S A 115:E11359-E11368

Showing the most recent 10 out of 296 publications