The goal of this NEI Center Core application is to enhance the research activities of NEI-funded investigators at The University of Iowa. This will be achieved by providing a complement of Service Cores. Each Core will offer a set of services - performed by skilled technical staff and supervised by experienced NEI-funded faculty members, employing standardized, automated procedures when possible. The combination of centralization (allowing specialization and concomitant increases in efficiency) and the breadth of services available from the various Core Modules are expected to provide utility and increased productivity to all vision researchers at The University of Iowa. This supports three primary foci: 1) histological and ultrastructural studies, 2) detailed phenotyping in the mouse, and 3) computational analysis of large-scale image and genotype data. These capabilities all require specialized equipment and highly trained staff that would be inefficient to duplicate in every lab employing these techniques.

Public Health Relevance

The visual sciences research cores centralize common research techniques so work is performed in an efficient and standardized way without the need to duplicate equipment and specialized staff. The services available from the cores provide utility and increased productivity to all vision research at The University of Iowa.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY025580-02
Application #
9334864
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
2016-09-01
Project End
2021-08-31
Budget Start
2017-09-01
Budget End
2018-08-31
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Iowa
Department
Pediatrics
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Schnieders, M J; Goar, W; Griess, M et al. (2018) A novel mutation (LEU396ARG) in OPA1 is associated with a severe phenotype in a large dominant optic atrophy pedigree. Eye (Lond) 32:843-845
Zeng, Shemin; Wen, Kuo-Kuang; Workalemahu, Grefachew et al. (2018) Imidazole Compounds for Protecting Choroidal Endothelial Cells from Complement Injury. Sci Rep 8:13387
Dutca, Laura M; Rudd, Danielle; Robles, Victor et al. (2018) Effects of sustained daily latanoprost application on anterior chamber anatomy and physiology in mice. Sci Rep 8:13088
Abramoff, Michael D; Fort, Patrice E; Han, Ian C et al. (2018) Approach for a Clinically Useful Comprehensive Classification of Vascular and Neural Aspects of Diabetic Retinal Disease. Invest Ophthalmol Vis Sci 59:519-527
Giacalone, Joseph C; Sharma, Tasneem P; Burnight, Erin R et al. (2018) CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells. Curr Protoc Stem Cell Biol 44:5B.7.1-5B.7.22
Chirco, Kathleen R; Lewis, Carly J; Scheetz, Todd E et al. (2018) Evaluation of sFLT1 protein levels in human eyes with the FLT1 rs9943922 polymorphism. Ophthalmic Genet 39:68-72
Anderson, Michael G; Meyer, Kacie J; Hedberg-Buenz, Adam et al. (2018) Update on Animal Models of Exfoliation Syndrome. J Glaucoma 27 Suppl 1:S78-S82
Inamdar, Shivangi M; Lankford, Colten K; Laird, Joseph G et al. (2018) Analysis of 14-3-3 isoforms expressed in photoreceptors. Exp Eye Res 170:108-116
Wagoner, Michael D; Bohrer, Laura R; Aldrich, Benjamin T et al. (2018) Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells. Biol Open 7:
Wiley, Luke A; Burnight, Erin R; Kaalberg, Emily E et al. (2018) Assessment of Adeno-Associated Virus Serotype Tropism in Human Retinal Explants. Hum Gene Ther 29:424-436

Showing the most recent 10 out of 26 publications