Genetics and in particular, genetic-based approaches such as transgenes and viruses that enable researchers to express proteins of interest in desired sets of neurons in the retina and brain, are pivotal to make significant progress in modern basic visual neuroscience and toward the treatment of visual disorders. The last decade has brought forth a wide and powerful arsenal of genetic tools for identifying the neurons that comprise the visual system of flies and rodents. Because they enable delivery of a wide range of gene cargo, such tools also allow for selective manipulation of cells of interest. Indeed, in comparison to just a decade ago, nowadays it is straightforward to label a given cell type in vivo, and thereby visualize its unique morphology, and then compare it to other cells of different types, selectivity target them for electrophysiology, calcium- or voltage-dye imaging, and then reversibly silence or activate them. Last but not least, genetic tools can be leveraged to explore the signature pattern of RNA expression present in different cell types in order to probe their homology across species and/or relevance to mutations associated with human diseases.
NEUROGENETICS OF VISION NARRATIVE Genetic-based approaches such as transgenes and viruses are pivotal to make significant progress in modern basic visual neuroscience and toward the treatment of visual disorders. These will be designed and produced by this Core, along with dissemination of results and promotion of collaborative, innovative uses.
| Davidson, Benjamin; Kalitzeos, Angelos; Carroll, Joseph et al. (2018) Automatic Cone Photoreceptor Localisation in Healthy and Stargardt Afflicted Retinas Using Deep Learning. Sci Rep 8:7911 |
| DiCarlo, James E; Mahajan, Vinit B; Tsang, Stephen H (2018) Gene therapy and genome surgery in the retina. J Clin Invest 128:2177-2188 |
| Wu, Suqian; Chang, Kun-Che; Nahmou, Michael et al. (2018) Induced Pluripotent Stem Cells Promote Retinal Ganglion Cell Survival After Transplant. Invest Ophthalmol Vis Sci 59:1571-1576 |
| Li, Jinliang; Aponte Paris, Shania; Thakur, Hrishikesh et al. (2018) Muscle A-kinase-anchoring protein-?-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D. J Biol Chem : |
| Wu, Suqian; Chang, Kun-Che; Goldberg, Jeffrey L (2018) Retinal Cell Fate Specification. Trends Neurosci 41:165-167 |
| Galvao, Joana; Iwao, Keiichiro; Apara, Akintomide et al. (2018) The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration. Invest Ophthalmol Vis Sci 59:2736-2747 |
| Jauregui, Ruben; Thomas, Amanda L; Liechty, Benjamin et al. (2018) SCAPER-associated nonsyndromic autosomal recessive retinitis pigmentosa. Am J Med Genet A : |
| Chopra, N; Gervasio, K A; Kalosza, B et al. (2018) Gun trauma and ophthalmic outcomes. Eye (Lond) 32:687-692 |
| Sredar, Nripun; Fagbemi, Oladipo E; Dubra, Alfredo (2018) Sub-Airy Confocal Adaptive Optics Scanning Ophthalmoscopy. Transl Vis Sci Technol 7:17 |
| Moss, Heather E; Vangipuram, Gautam; Shirazi, Zainab et al. (2018) Retinal Vessel Diameters Change Within 1 Hour of Intracranial Pressure Lowering. Transl Vis Sci Technol 7:6 |
Showing the most recent 10 out of 21 publications
