This application responds to RFA-OD-09-005, """"""""Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers (P30). We propose to hire a new Assistant Professor in the area of Stem Cell Research, with a specific interest in either Neurological Stem Cell Biology or Mesenchymal Stem Cell Biology as an Investigator in the San Antonio Institute for Cellular and Molecular Primatology (SAICMP), a Biomedical Core Center, and the Department of Biology at UTSA, as a tenure-track Assistant Professor. UTSA is an Eligible Institution under the general guidelines of this RFA, and is a specifically targeted institution for this RFA as an Hispanic-Serving Institution. The mission of the SAICMP is to promote interactive research utilizing primate and other relevant model systems to investigate the basic biology of stem cells and their differentiated derivatives, and especially to optimize and test protocols for potential therapeutic application in human patients. Past experiences involving the premature application of either gene therapy or more recent stem-cell-based therapeutic applications to human patients have demonstrated the dangers of adapting these protocols to humans prior to ensuring their efficacy and safety by pre-clinical testing in relevant animal model systems. We define an excellent opportunity for a new hire at the Assistant Professor (tenure-track) level, with very strong institutional support and potential for development of a highly successful career in academia and biomedical research. We commit extensive institutional support in terms of ongoing state-supported salary, individual laboratory space, a tenure-track position, access to all resources afforded to all members of the SAICMP, the Department of Biology faculty, and/or the College of Sciences faculty at UTSA, and the opportunity to join a unique team of stem cell biologists working with a unique, but highly relevant nonhuman primate model for studies of stem-cell-based therapeutic approaches. Thus, this application is responsive to the RFA by seeking funds that will allow the creation of a position (job) that will not otherwise be made available during the coming year.

Public Health Relevance

This application is relevant to the mission of the NIGMS because the funds will contribute to our overall goal to establish the baboon as a clinically relevant, nonhuman primate model system for developing, testing and optimizing protocols for novel stem-cell-based therapeutic approaches to be applied to the treatment of heretofore intractable diseases or debilitations.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM092334-01
Application #
7856579
Study Section
Special Emphasis Panel (ZGM1-BRT-9 (RA))
Program Officer
Sheehy, Paul A
Project Start
2009-09-30
Project End
2011-08-31
Budget Start
2009-09-30
Budget End
2010-08-31
Support Year
1
Fiscal Year
2009
Total Cost
$316,750
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
800189185
City
San Antonio
State
TX
Country
United States
Zip Code
78249
Hermann, Brian P; Cheng, Keren; Singh, Anukriti et al. (2018) The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids. Cell Rep 25:1650-1667.e8
Kotzur, Travis; Benavides-Garcia, Roberto; Mecklenburg, Jennifer et al. (2017) Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy. Reprod Biol Endocrinol 15:7
Mutoji, Kazadi; Singh, Anukriti; Nguyen, Thu et al. (2016) TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse Testis. Biol Reprod 95:117
Lovelace, Dawn L; Gao, Zhen; Mutoji, Kazadi et al. (2016) The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia. Development 143:1893-906
Hermann, Brian P; Mutoji, Kazadi N; Velte, Ellen K et al. (2015) Transcriptional and translational heterogeneity among neonatal mouse spermatogonia. Biol Reprod 92:54
Benavides-Garcia, Roberto; Joachim, Rose; Pina, Nancy A et al. (2015) Granulocyte colony-stimulating factor prevents loss of spermatogenesis after sterilizing busulfan chemotherapy. Fertil Steril 103:270-80.e8
Sandstrom, Richard S; Foret, Michael R; Grow, Douglas A et al. (2014) Epigenetic regulation by chromatin activation mark H3K4me3 in primate progenitor cells within adult neurogenic niche. Sci Rep 4:5371