The Biometery Core of the Center for Colon Cancer Research (CCCR) provides statistical and mathematical support to target, senior, and junior CCCR investigators. Assistance and support are in the designing of the scientific experiments, studies, and surveys;developing statistical and mathematical models appropriate for the research problems;performing appropriates statistical analyses of data arising from the projects;assessing the validity of the methods used in the analyses of data and developing new methods when appropriates;critiquing and improving statistical portions of manuscripts for publications and grant proposals;writing publication-quality reports pertaining to the results of the statistical analyses for grant applciations and manuscripts for publications;and performing basic research to develop new statistical methodology of relevance to cancer researchers. Biometry Core personnel actively participate in the research of investigators through one-on-one consultations and by providing feedback during research To increase awareness of CCCR investigators on the important and crucial role of Statistics in scientific research, the Biometry Core will provide training workshops on statistical methodology relevant to cancer research. Increasing the statistical knowledge of CCCR investigators will also further enhance collaborative research and improve statistical consultation sessions. Through the statistical support provided by the Biometry Core to CCCR investigators, it is hoped that the validity and utility of the colon cancer research performed by the investigators will be enhanced. This will have the consequence of contributing in masking further inroads to the search for a cure and the prevention of colon cancer. Strategies for financially sustaining the Core post 2017 are to implement a Service-for-Fee arrangement with investigators who seek Core services and to have line item components in the budget of project grants and/or grant proposal for Core personnel

Public Health Relevance

Comprehensive statistical analysis of biological data is essential for making firm conclusions. The CCCR supports a core that provides investigators with the ability to plan experiments and analyze results in a statistically rigorous fashion.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM103336-01A1
Application #
8543936
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Project Start
Project End
Budget Start
2013-09-10
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$48,899
Indirect Cost
$13,899
Name
University of South Carolina at Columbia
Department
Type
DUNS #
041387846
City
Columbia
State
SC
Country
United States
Zip Code
29208
Liang, Jiaxin; Chen, Mengqian; Hughes, Daniel et al. (2018) CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer Res 78:6594-6606
Liu, Shou; Lee, Ji Shin; Jie, Chunfa et al. (2018) HER2 Overexpression Triggers an IL1? Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance. Cancer Res 78:2040-2051
Wyatt, Michael D; Reilly, Nicole M; Patel, Shikha et al. (2018) Thiopurine-induced mitotic catastrophe in Rad51d-deficient mammalian cells. Environ Mol Mutagen 59:38-48
Liu, Changlong; Banister, Carolyn E; Weige, Charles C et al. (2018) PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids. Proc Natl Acad Sci U S A 115:E5066-E5075
Kaur, Kamaljeet; Saxena, Arpit; Debnath, Irina et al. (2018) Antibiotic-mediated bacteriome depletion in ApcMin/+ mice is associated with reduction in mucus-producing goblet cells and increased colorectal cancer progression. Cancer Med 7:2003-2012
Eberth, Jan M; Thibault, Annie; Caldwell, Renay et al. (2018) A statewide program providing colorectal cancer screening to the uninsured of South Carolina. Cancer 124:1912-1920
Zhang, Yu; Davis, Celestia; Shah, Sapana et al. (2017) IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis. Mol Carcinog 56:272-287
McDermott, Martina S J; Chumanevich, Alexander A; Lim, Chang-Uk et al. (2017) Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget 8:12558-12575
Peña, Edsel A; Wu, Wensong; Piegorsch, Walter et al. (2017) Model Selection and Estimation with Quantal-Response Data in Benchmark Risk Assessment. Risk Anal 37:716-732
Abdalla, Aya; Atcherley, Christopher W; Pathirathna, Pavithra et al. (2017) In Vivo Ambient Serotonin Measurements at Carbon-Fiber Microelectrodes. Anal Chem 89:9703-9711

Showing the most recent 10 out of 51 publications