Based on the success ofthe initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years. With the foundation of a long-standing Immunology Program, which has now been substantially enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this expanded investigator base, a Phase III COBRE award will provide the resources to build the needed infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic science to translational immunological research. This infrastructure will include the continued mentored development of our immunlogical faculty, especially those investigators previously supported by COBRE; expansion ofthe COBRE Cores and their full integration with existing complementary cores and shared services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and """"""""Lung Biology"""""""" COBREs at Dartmouth and the Univesrity of Vermont;and an enhanced Pilot Projdect Program with targeting to mentored, collaborative, and/or translational/human systems research. Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, impact.

Public Health Relevance

The immune system is central to a variety of disease states, from protective responses to microbial infections and tumors, to unwanted inflammation and immunopathology characteristic of allergy, autoimmunity, etc. A better understanding of how to regulate the immune system is needed to create better vaccines, or to limit immune responses in syndromes resulting from an overzealous recognition of non-dangerous antigen.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103415-04
Application #
8655174
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Gorospe, Rafael
Project Start
2011-07-01
Project End
2016-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
4
Fiscal Year
2014
Total Cost
$1,177,189
Indirect Cost
$432,024
Name
Dartmouth College
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Rodriguez-Garcia, Marta; Fortier, Jared M; Barr, Fiona D et al. (2018) Aging impacts CD103+ CD8+ T cell presence and induction by dendritic cells in the genital tract. Aging Cell 17:e12733
Ribeiro de Souza, Ana Luiza; Marra, Kayla; Gunn, Jason et al. (2018) Optimizing Glioma Detection Using an EGFR-Targeted Fluorescent Affibody. Photochem Photobiol 94:1167-1171
Patel, Mickey V; Shen, Zheng; Wira, Charles R (2018) Poly (I:C) and LPS induce distinct immune responses by ovarian stromal fibroblasts. J Reprod Immunol 127:36-42
Rodriguez-Garcia, Marta; Fortier, Jared M; Barr, Fiona D et al. (2018) Isolation of Dendritic Cells from the Human Female Reproductive Tract for Phenotypical and Functional Studies. J Vis Exp :
Goodwin, Eileen; Gilman, Morgan S A; Wrapp, Daniel et al. (2018) Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity 48:339-349.e5
Malik, Brian T; Byrne, Katelyn T; Vella, Jennifer L et al. (2017) Resident memory T cells in the skin mediate durable immunity to melanoma. Sci Immunol 2:
Rodriguez-Garcia, Marta; Patel, Mickey V; Shen, Zheng et al. (2017) Tenofovir Inhibits Wound Healing of Epithelial Cells and Fibroblasts from the Upper and Lower Human Female Reproductive Tract. Sci Rep 8:45725
Mustachio, Lisa Maria; Lu, Yun; Tafe, Laura J et al. (2017) Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer. Mol Cancer Res 15:905-914
Farzan, Shohreh F; Howe, Caitlin G; Zens, Michael S et al. (2017) Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study. Environ Health Perspect 125:127002
Shen, Zheng; Rodriguez-Garcia, Marta; Ochsenbauer, Christina et al. (2017) Characterization of immune cells and infection by HIV in human ovarian tissues. Am J Reprod Immunol 78:

Showing the most recent 10 out of 49 publications