The overall goal of the Center of Biomedical Research Excellence (COBRE) in Neuroscience at the University of Vermont (UVM), established in 2001, has been to integrate and expand neuroscience research and training at UVM by building a collaborative intellectual infrastructure, developing cutting-edge shared core facilities, supporting recruitment of new junior faculty, and by providing research project and pilot project funding for neuroscience faculty in multiple colleges. The Neuroscience COBRE expanded interdisciplinary neuroscience research and promoted translational research by increasing the interaction between basic and clinical neuroscientists. COBRE funding has been instrumental in developing an excellent research infrastructure that has allowed the neuroscience community to compete successfully for new institutional funds and extramural support. As the neuroscience faculty enterprise has grown, neuroscience has been designated an area of research and training emphasis at UVM. The primary objective of the next grant cycle is to build upon our success and continue to support the infrastructure of neuroscience research and training at UVM. The goals are: Goal 1: To support the intellectual environment and research opportunities of neuroscientists at UVM by (1) maintaining a vigorous mentoring program to promote success of pilot project grant directors and newly recruited junior neuroscience investigators, (2) supporting a University-wide Neuroscience Seminar Series and Annual Retreat, (3) supporting Pilot Project grants, (4) facilitating the growth and productivity of the university-wide Neuroscience Graduate Program and (5) facilitating dialogue between basic and clinical scientists that promotes development of collaborative and translational research. Goal 2: To support the infrastructure for neuroscience research and training at UVM by fostering the continued growth of two Neuroscience COBRE multi-user research cores: an Imaging/Physiology Core and Cell/Molecular Biology Core. In particular, the Neuroscience COBRE grant will ensure continued growth in sophistication of equipment and research training offered through the Imaging/Physiology Core and Cell/Molecular Biology Core.

Public Health Relevance

The primary goal of the Neuroscience COBRE is to support the infrastructure of neuroscience research and training at the University of Vermont (UVM). This support will allow investigators to ask clinically relevant questions and answer them using state-of-the-art facilities. UVM is the only doctoral degree granting institution in a state with limited resources due to its tax base of fewer than 625,000 people. Continued support of the Neuroscience COBRE by the National Center for Research Resources over the next funding cycle will ensure a return on investment that will benefit the University, the State of Vermont and the national research enterprise.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Canto, Maria Teresa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Vermont & St Agric College
Anatomy/Cell Biology
Schools of Medicine
United States
Zip Code
Harraz, Osama F; Longden, Thomas A; Hill-Eubanks, David et al. (2018) PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells. Elife 7:
Sheehe, Jessica L; Bonev, Adrian D; Schmoker, Anna M et al. (2018) Oxidation of cysteine 117 stimulates constitutive activation of the type I? cGMP-dependent protein kinase. J Biol Chem 293:16791-16802
Parsons, Rodney L; May, Victor (2018) PACAP-Induced PAC1 Receptor Internalization and Recruitment of Endosomal Signaling Regulate Cardiac Neuron Excitability. J Mol Neurosci :
Heppner, David E; Dustin, Christopher M; Liao, Chenyi et al. (2018) Direct cysteine sulfenylation drives activation of the Src kinase. Nat Commun 9:4522
Harraz, Osama F; Longden, Thomas A; Dabertrand, Fabrice et al. (2018) Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion. Proc Natl Acad Sci U S A 115:E3569-E3577
Tacoma, R; Gelsinger, S L; Lam, Y W et al. (2017) Exploration of the bovine colostrum proteome and effects of heat treatment time on colostrum protein profile. J Dairy Sci 100:9392-9401
Longden, Thomas A; Dabertrand, Fabrice; Koide, Masayo et al. (2017) Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow. Nat Neurosci 20:717-726
Villalba, Nuria; Sackheim, Adrian M; Nunez, Ivette A et al. (2017) Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1-Dependent Uncoupling of Endothelial Nitric Oxide Synthase. J Neurotrauma 34:192-203
Heppner, Thomas J; Hennig, Grant W; Nelson, Mark T et al. (2017) Rhythmic Calcium Events in the Lamina Propria Network of the Urinary Bladder of Rat Pups. Front Syst Neurosci 11:87
Missig, Galen; Mei, Linda; Vizzard, Margaret A et al. (2017) Parabrachial Pituitary Adenylate Cyclase-Activating Polypeptide Activation of Amygdala Endosomal Extracellular Signal-Regulated Kinase Signaling Regulates the Emotional Component of Pain. Biol Psychiatry 81:671-682

Showing the most recent 10 out of 112 publications