The overarching goal ofthe Physiology Phenotyping Core (PPC) is to promote the health and welfare of individuals with sensory and/or nervous system disorders by providing state-of-the-art core support that will facilitate the integration of physiological, molecular and genetic disciplines into a comprehensive biomedical research program. To achieve that goal, the PPC offers a broad range of sensory and neurophysiology services, including measurement of evoked near- and far-field potentials, otoacoustic emissions, single- and multi-neuron recordings, and micro-pharmacology support. PPC staff are available to participate actively in all aspects of data acquisition, data reduction, data analyses and reporting functions associated with each investigation. The specific goals of the PPC are to provide state-of-the-art technical, conceptual, and scientific support for investigators conducting sensory and neurophysiological studies, to develop and incorporate novel methodologies, such as optogenetic techniques, and to advise and mentor investigators in an effort to promote an interdisciplinary research environment and thereby enhance opportunities to successfully compete for research funding on a national scale. The PPC came into service in Phase II ofthe COBRE in response to demand associated with the successful creation of mouse models with genetic and/or molecular features with significant clinical implications. Moving into Phase III of operation, a fee structure for services has been developed to sustain the facility in the long term, and a high program priority is to expand the base of user support to include investigators on a statewide and regional basis and in doing so advance biomedical research initiatives aimed at understanding the function of normal and abnormal nervous and sensory systems.
Access to the research tools available in the Physiology Phenotyping Core is intended to broaden the regional biomedical research base by incorporating neurophysiological and sensory physiology techniques into an existing interdisciplinary neuroscience research program and by providing expert scientific and technical services to facility users wishing to study the physiology of animal models with significant nervous svstem and sensnrv health relevance.
|Cruz, Eric; Kumar, Sushil; Yuan, Li et al. (2018) Intracellular amyloid beta expression leads to dysregulation of the mitogen-activated protein kinase and bone morphogenetic protein-2 signaling axis. PLoS One 13:e0191696|
|Liu, Huizhan; Chen, Lei; Giffen, Kimberlee P et al. (2018) Cell-Specific Transcriptome Analysis Shows That Adult Pillar and Deiters' Cells Express Genes Encoding Machinery for Specializations of Cochlear Hair Cells. Front Mol Neurosci 11:356|
|Wehrkamp, Cody J; Natarajan, Sathish Kumar; Mohr, Ashley M et al. (2018) miR-106b-responsive gene landscape identifies regulation of Kruppel-like factor family. RNA Biol 15:391-403|
|Lopez, Wilfredo; Page, Alexis M; Carlson, Darby J et al. (2018) Analysis of immune-related genes during Nora virus infection of Drosophila melanogaster using next generation sequencing. AIMS Microbiol 4:123-139|
|Leiferman, Amy; Shu, Jiang; Grove, Ryan et al. (2018) A diet defined by its content of bovine milk exosomes and their RNA cargos has moderate effects on gene expression, amino acid profiles and grip strength in skeletal muscle in C57BL/6 mice. J Nutr Biochem 59:123-128|
|Miura, Hiromi; Quadros, Rolen M; Gurumurthy, Channabasavaiah B et al. (2018) Easi-CRISPR for creating knock-in and conditional knockout mouse models using long ssDNA donors. Nat Protoc 13:195-215|
|Won, Harim I; Schulze, Thomas T; Clement, Emalie J et al. (2018) De novo Assembly of the Burying Beetle Nicrophorus orbicollis (Coleoptera: Silphidae) Transcriptome Across Developmental Stages with Identification of Key Immune Transcripts. J Genomics 6:41-52|
|Xia, Xiaohuan; Teotia, Pooja; Ahmad, Iqbal (2018) Lin28a regulates neurogliogenesis in mammalian retina through the Igf signaling. Dev Biol 440:113-128|
|Baranovskiy, Andrey G; Duong, Vincent N; Babayeva, Nigar D et al. (2018) Activity and fidelity of human DNA polymerase ? depend on primer structure. J Biol Chem 293:6824-6843|
|Booth, Kevin T; Askew, James W; Talebizadeh, Zohreh et al. (2018) Splice-altering variant in COL11A1 as a cause of nonsyndromic hearing loss DFNA37. Genet Med :|
Showing the most recent 10 out of 72 publications