Abstract

This Center Grant requests CORE and implementation support for a broadly based program for the study of Mental Retardation and Developmental Disabilities. The scientific basis of the research program rests upon investigation in two major program areas: a) Genetics and b) Neuroscience - Biological Neurogenetics, Developmental Neurology, Cellular Neuroscience, Developmental Neurology, Epilepsy Studies, Ophthalmology. Additional closely related laboratories: Developmental Biology and Endocrinology have been established. Clinical and Behavioral Research is centered in three additional laboratories, i.e., Neuroepidemiology, Clinical Neurophysiology/Behavior, and Neuropsychology and a new program of neonatal neurology clinical research is planned. The multidisciplinary approaches include fields of pediatrics, neurology, neurosurgery, neuropathology, psychiatry and ophthalmology, and the relevant basic science fields of genetics and the various neurosciences. The laboratory program is housed in over 50,000 square feet of the Enders Pediatric Sciences Building. The objective of the program is to provide a scientific and clinical basis for the better understanding of the factors leading to Mental Retardation and Developmental Disabilities, and to apply this information to the prevention of these disorders, and to the management of the handicapped individual.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD018655-11
Application #
3102973
Study Section
Mental Retardation Research Committee (HDMR)
Project Start
1983-01-01
Project End
1996-07-31
Budget Start
1992-08-01
Budget End
1993-07-31
Support Year
11
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Sieker, Jakob T; Proffen, Benedikt L; Waller, Kimberly A et al. (2018) Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis. J Orthop Res :
Waber, Deborah P; Bryce, Cyralene P; Girard, Jonathan M et al. (2018) Parental history of moderate to severe infantile malnutrition is associated with cognitive deficits in their adult offspring. Nutr Neurosci 21:195-201
Leviton, Alan; Dammann, Olaf; Allred, Elizabeth N et al. (2018) Neonatal systemic inflammation and the risk of low scores on measures of reading and mathematics achievement at age 10 years among children born extremely preterm. Int J Dev Neurosci 66:45-53
O'Connell, Amy E; Zhou, Fanny; Shah, Manasvi S et al. (2018) Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet 103:131-137
Hirschberger, Rachel G; Kuban, Karl C K; O'Shea, Thomas M et al. (2018) Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm. Pediatr Neurol 79:45-52
Korzeniewski, Steven J; Allred, Elizabeth N; O'Shea, T Michael et al. (2018) Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation. Transl Psychiatry 8:115
Sveinsdóttir, Kristbjörg; Ley, David; Hövel, Holger et al. (2018) Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants. Neonatology 114:46-52
Gilles, Floyd; Gressens, Pierre; Dammann, Olaf et al. (2018) Hypoxia-ischemia is not an antecedent of most preterm brain damage: the illusion of validity. Dev Med Child Neurol 60:120-125
Laprairie, Robert B; Petr, Geraldine T; Sun, Yan et al. (2018) Huntington's disease pattern of transcriptional dysregulation in the absence of mutant huntingtin is produced by knockout of neuronal GLT-1. Neurochem Int :
Kambara, Tracy K; Ramsey, Kathryn M; Dove, Simon L (2018) Pervasive Targeting of Nascent Transcripts by Hfq. Cell Rep 23:1543-1552

Showing the most recent 10 out of 1442 publications