This proposal seeks support for new faculty recruitment to enhance research resources for the Nanomedicine Research Center (NRC) at the University of South Florida College of Medicine, whose mission is to serve as a catalyst for advancing the basic and translational aspects nanomedicine for Heart, Lung and Blood disorders. The NRC goals are to: (i) develop innovative and integrative nano- and cell-technologies, (ii) nurture and foster the transition of these advanced technologies from the laboratory to the clinic, (iii) foster university-industry and Florida-wide collaborations in nanomedicine, tissue engineering and cell technologies. The NRC members (about 18) include faculty from the colleges of Arts and Sciences, Engineering, Nursing Medicine and Public Health. The NRC seeks to create a multidisciplinary team of biologists, engineers, scientists and clinicians, working in a coordinated and focused effort, to develop integrated technology to accelerate the translation of molecular and cellular knowledge into nanotechnology applications for medical and cell technologies. The NRC is located at the College of Medicine and has satellite laboratories at the VA Hospital and Interdisciplinary Research Building. The Center currently has 6 core faculty and 12 adjunct faculty and several support staff, postdoctoral fellows and graduate students. The NRC has identified two areas of research for enhancement in order of importance: (i) immune cell-targeted therapeutics for lung diseases and (ii) stem cell-blood differentiation on 3-D nanomatrices. The NRC has identified Mary Markiewicz, PhD, Instructor at Washington Univ., St Louis as a potential candidate for tenure-track faculty at the NRC. The College of Medicine has made a commitment for this position with salary and start-up funding for support personnel, equipment and supplies following the completion of P-30 support. Dr. Mary Markiwicz's basic research on NKG2D as a potential immunomodulatory system for respiratory viral infections pursued at the NRC is excellent and is expected to enhance the NRC's nanomedicine application in basic and translational research. This support is not only expected to provide jobs for 4 highly trained individuals, but will significantly affect their lives and contributions to nanomedicine research. This proposal seeks support for new faculty recruitment to enhance research resources for the Nanomedicine Research Center (NRC) at the University of South Florida College of Medicine, whose mission is to serve as a catalyst for advancing the basic and translational aspects nanomedicine for heart lung and blood disorders. This support will permit creation of four jobs to highly qualified individuals.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Center Core Grants (P30)
Project #
5P30HL101265-02
Application #
7936169
Study Section
Special Emphasis Panel (ZHL1-CSR-E (O1))
Program Officer
Rothgeb, Ann E
Project Start
2009-09-30
Project End
2013-06-30
Budget Start
2010-09-01
Budget End
2013-06-30
Support Year
2
Fiscal Year
2010
Total Cost
$664,500
Indirect Cost
Name
University of South Florida
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
069687242
City
Tampa
State
FL
Country
United States
Zip Code
33612
Bird, Gregory H; Boyapalle, Sandhya; Wong, Terianne et al. (2014) Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection. J Clin Invest 124:2113-24
Nagaraj, Srinivas; Youn, Je-In; Gabrilovich, Dmitry I (2013) Reciprocal relationship between myeloid-derived suppressor cells and T cells. J Immunol 191:17-23
Dixit, Suraj; Das, Mahasweta; Alwarappan, Subbiah et al. (2013) Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery. RSC Adv 3:2727-2735
Huls, Natalie Frey; Phan, Manh-Huong; Kumar, Arun et al. (2013) Transverse susceptibility as a biosensor for detection of Au-Fe?O? nanoparticle-embedded human embryonic kidney cells. Sensors (Basel) 13:8490-500
Nagaraj, Srinivas; Gabrilovich, Dmitry I (2012) Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells. Semin Cancer Biol 22:282-8
Nelson, Allison; Nair, Sajitha; Nagaraj, Srinivas (2012) CD4(+) T cells suppress immune response to cancer: novel targets for antitumor efforts. Expert Rev Clin Immunol 8:401-3
Brar, Tina; Nagaraj, Srinivas; Mohapatra, Shyam (2012) Microbes and asthma: the missing cellular and molecular links. Curr Opin Pulm Med 18:14-22
Nagaraj, Srinivas; Nelson, Allison; Youn, Je-in et al. (2012) Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling. Cancer Res 72:928-38
Wang, Xiaoqin; Raulji, Payal; Mohapatra, Shyam S et al. (2011) Natriuretic peptide receptor a as a novel target for prostate cancer. Mol Cancer 10:56
Kumar, Arun; Glaum, Mark; El-Badri, Nagwa et al. (2011) Initial observations of cell-mediated drug delivery to the deep lung. Cell Transplant 20:609-18

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