Columbia University Medical Center (CUMC) contains several large research programs in basic cardiovascular research and clinical heart failure. In response to this P30 program, the Department of Medicine and the Cardiovascular Research Initiative (CVRI) have selected a recently recruited new faculty member whose tenure track appointment will begin on July 1, 2009. Our proposed new faculty member is completing his training in cardiology in the CUMC program, one of the most selective programs in the country. Prior to this he performed studies on the basic biology of skeletal muscle and its abnormalities in patients with heart failure. The proposed research includes clinical and basic studies of the effects of heart failure on muscle biology, concentrating on protein turnover and lipid metabolism. The central hypothesis of this application is that common gene expression patterns and metabolic derangements determine structural and functional changes in the skeletal muscle and myocardium of patients with heart failure, and that those changes are reversible after hemodynamic improvement through ventricular assist device placement. A series of senior collaborators at CUMC will assist in these studies. A career guidance program that includes faculty from several departments has been developed to insure the success of this recruit. Funds from this grant will support the purchase of equipment, provide operating expenses for the proposed clinical and basic research, and will allow the hiring of support staff to assist with the 2 year studies. The Department of Medicine and Division of Cardiology have committed additional funds that guarantee full salary support and some laboratory operating expenses for five years. A major goal of the Department and CVRI is to increase interaction between our clinical and research activities in cardiovascular disease. This recruitment is an effort to do that by adding an outstanding new faculty member focusing on translational research. Heart failure is an expanding worldwide epidemic that already affects more than 5 million people in the US. Exercise intolerance and muscle wasting result from impaired peripheral metabolism and are predictors of mortality in heart failure.
This research aims to understand the fundamental interactions of skeletal muscle and myocardial metabolism and function with the ultimate goal of discovering new therapies to prevent or treat the functional decline in patients with heart failure.
Heart failure is an expanding worldwide epidemic that already affects more than 5 million people in the US. Exercise intolerance and muscle wasting result from impaired peripheral metabolism and are predictors of mortality in heart failure. This research aims to understand the fundamental interactions of skeletal muscle and myocardial metabolism and function with the ultimate goal of discovering new therapies to prevent or treat the functional decline in patients with heart failure.
|Ji, Ruiping; Akashi, Hirokazu; Drosatos, Konstantinos et al. (2017) Increased de novo ceramide synthesis and accumulation in failing myocardium. JCI Insight 2:|
|Brunjes, Danielle L; Dunlop, Mark; Wu, Christina et al. (2016) Analysis of Skeletal Muscle Torque Capacity and Circulating Ceramides in Patients with Advanced Heart Failure. J Card Fail 22:347-55|
|Lee, Mike; Akashi, Hirokazu; Kato, Tomoko S et al. (2016) Vascular inflammation and abnormal aortic histomorphometry in patients after pulsatile- and continuous-flow left ventricular assist device placement. J Heart Lung Transplant 35:1085-91|
|Coromilas, Ellie; Que-Xu, Em-Claire; Moore, D'Vesharronne et al. (2016) Dynamics and prognostic role of galectin-3 in patients with advanced heart failure, during left ventricular assist device support and following heart transplantation. BMC Cardiovasc Disord 16:138|
|Givens, Raymond C; Dardas, Todd; Clerkin, Kevin J et al. (2015) Outcomes of Multiple Listing for Adult Heart Transplantation in the United States: Analysis of OPTN Data From 2000 to 2013. JACC Heart Fail 3:933-41|
|Wu, Christina; Kato, Tomoko S; Ji, Ruiping et al. (2015) Supplementation of l-Alanyl-l-Glutamine and Fish Oil Improves Body Composition and Quality of Life in Patients With Chronic Heart Failure. Circ Heart Fail 8:1077-87|
|Zizola, Cynthia; Kennel, Peter J; Akashi, Hirokazu et al. (2015) Activation of PPAR? signaling improves skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic left ventricular dysfunction. Am J Physiol Heart Circ Physiol 308:H1078-85|
|Martin, Spencer T; Kato, Tomoko S; Farr, Maryjane et al. (2015) Similar survival in patients following heart transplantation receiving induction therapy using daclizumab vs. basiliximab. Circ J 79:368-374|
|Farr, Maryjane; Mitchell, James; Lippel, Matthew et al. (2015) Combination of liver biopsy with MELD-XI scores for post-transplant outcome prediction in patients with advanced heart failure and suspected liver dysfunction. J Heart Lung Transplant 34:873-82|
|Khawaja, Tuba; Greer, Christine; Thadani, Samir R et al. (2015) Increased regional epicardial fat volume associated with reversible myocardial ischemia in patients with suspected coronary artery disease. J Nucl Cardiol 22:325-33|
Showing the most recent 10 out of 40 publications