This application is seeking support for a new Assistant Professor in the Center for Regenerative Medicine (CRM), at the Massachusetts General Hospital (MGH), Harvard Medical School. This individual will be located in recently completed laboratory and office space for CRM, on the MGH main campus, as part of a 10 faculty physically adjoined unit within the Simches Building housing five interdisciplinary centers. The CRM space is open lab format to encourage interaction and includes GMP level facilities for clinical grade cell preparations, a polymer handling suite for bioengineered matrix construction and a computational biology suite housing a cadre of bioinformatics experts. The CRM is a multidisciplinary organization established in 2003 incorporating individuals from the Departments of Medicine, Surgery, Neurosurgery, Cell Biology, Genetics and Stem Cell and Regenerative Biology. After review of over 70 candidates, a physician-scientist with a record of excellent research in lung developmental and regenerative biology as well as clinical expertise in lung disease was selected. This candidate, Dr. Jayaraj Rajagopal, is focused on the application of lung stem cells and regeneration to human lung disease.
Aims : 1.) To recruit a physician-scientist focusing on stem cell based approaches to human disease 2.) To establish a laboratory with state-of-the-art facilities to enhance our understanding and potential application of lung developmental biology to lung disease.3.) To foster the success of a future thought leader in regenerative medicine for lung disease. In contrast to recent progress in blood and cardiac stem cell biology, work in the lung remains underdeveloped. We wish to recruit a new faculty candidate to the Center for Regenerative Medicine at the Massachusetts General Hospital. We believe our candidate's interest in the therapeutic uses of lung stem cells and developmental biology will lay a foundation for regenerative medicine in the lung.
|Tata, Purushothama Rao; Chow, Ryan D; Saladi, Srinivas Vinod et al. (2018) Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Dev Cell 44:679-693.e5|
|Pardo-Saganta, Ana; Tata, Purushothama Rao; Law, Brandon M et al. (2015) Parent stem cells can serve as niches for their daughter cells. Nature 523:597-601|
|Pardo-Saganta, Ana; Law, Brandon M; Tata, Purushothama Rao et al. (2015) Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. Cell Stem Cell 16:184-97|
|Dowdall, Jayme R; Sadow, Peter M; Hartnick, Christopher et al. (2015) Identification of distinct layers within the stratified squamous epithelium of the adult human true vocal fold. Laryngoscope 125:E313-9|
|Zhao, Rui; Fallon, Timothy R; Saladi, Srinivas Vinod et al. (2014) Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Dev Cell 30:151-65|
|Tata, Purushothama Rao; Mou, Hongmei; Pardo-Saganta, Ana et al. (2013) Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature 503:218-23|
|Pardo-Saganta, Ana; Law, Brandon M; Gonzalez-Celeiro, Meryem et al. (2013) Ciliated cells of pseudostratified airway epithelium do not become mucous cells after ovalbumin challenge. Am J Respir Cell Mol Biol 48:364-73|
|Tata, Purushothama Rao; Pardo-Saganta, Ana; Prabhu, Mythili et al. (2013) Airway-specific inducible transgene expression using aerosolized doxycycline. Am J Respir Cell Mol Biol 49:1048-56|
|Kim, Jun Ki; Vinarsky, Vladimir; Wain, John et al. (2012) In vivo imaging of tracheal epithelial cells in mice during airway regeneration. Am J Respir Cell Mol Biol 47:864-8|
|Mou, Hongmei; Zhao, Rui; Sherwood, Richard et al. (2012) Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell 10:385-97|