The over-arching objectives of the Neuromedical Core (NMC) are to provide comprehensive clinical and? laboratory evaluations, scientific consultation, and mentorship, training, and community education in? NeuroAIDS. In the current funding period the NMC facilitated 79 research projects including observational? cohort studies, clinical-pathological investigations, imaging studies, clinical trials and international research? performed by collaborating investigators at UCSD and many other institutions. The HNRC's collaborating? investigators find data generated by the NMC, including neurological diagnostic formulations, antiretroviral? (ARV) treatment information, HIV disease staging information, viral loads and a variety of other clinical? laboratory measurements, to be essential for their data analyses and publications.? Recognizing that maintaining vitality and scientific relevance necessitates continual adaptation to the? changing needs of the HNRC research enterprise and the scientific agendas of its many principal? investigators and collaborators, we propose to enhance the NMC in this renewal in two ways. First, we will? add a pharmacology component that will focus on ARV drug penetration into the CMS. Second, we will? incorporate functions previously carried out by the Cellular Immunology and Fluids Core. The newly-organized? NMC is made up of three cooperative units, each comprising common resources (equipment,? supplies) and staff that interact on a daily basis: a Clinical Unit; a Patient-Derived Sample Unit; and a? Pharmacology & Biomarker Unit. Examples of scientific questions the Core will facilitate answering are? 1) What is the contributory role in neuroAIDS of co-pathogens and comorbidities such as hepatitis C virus? (HCV) and substance abuse? 2) Does cerebrospinal fluid (CSF) provide a useful window to evaluate? virus-host interactions and molecular pathogenesis in neuroAIDS? 3) What is the role of the CNS in viral? evolution, adaptation and the occurrence of ARV drug resistance? 4) How do host genetics influence HIV? neuropathogenesis?? By assisting investigators in widely diverging disciplines at all levels of project development, from? conceptualization of hypotheses to study implementation, analysis, interpretation and dissemination, the? NMC encourages the application of multiple scientific perspectives and stimulates interdisciplinary? collaboration and coordination. We will collaborate closely with the Neuroimaging, Neurobehavioral,? Neurovirology and Neurobiology Cores to further stimulate transdisciplinary aims. In addition to supporting? the performance of research research, the NMC also enhances and extends the effectiveness and public? health impact of new findings related to mental health and HIV/AIDS.?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH062512-08
Application #
7585177
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
8
Fiscal Year
2008
Total Cost
$421,506
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Faytell, Marika Pers; Doyle, Katie; Naar-King, Sylvie et al. (2018) Calendaring and alarms can improve naturalistic time-based prospective memory for youth infected with HIV. Neuropsychol Rehabil 28:1038-1051
Mehta, Sanjay R; Chaillon, Antoine; Gaines, Tommi L et al. (2018) Impact of Public Safety Policies on Human Immunodeficiency Virus Transmission Dynamics in Tijuana, Mexico. Clin Infect Dis 66:758-764
Hoenigl, Martin; Jain, Sonia; Moore, David et al. (2018) Substance Use and Adherence to HIV Preexposure Prophylaxis for Men Who Have Sex with Men1. Emerg Infect Dis 24:
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Moore, David J; Pasipanodya, Elizabeth C; Umlauf, Anya et al. (2018) Individualized texting for adherence building (iTAB) for methamphetamine users living with HIV: A pilot randomized clinical trial. Drug Alcohol Depend 189:154-160
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Hellmuth, Joanna; Milanini, Benedetta; Masliah, Eliezer et al. (2018) A neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder. Neurocase 24:213-219
Hoenigl, Martin; Moser, Carlee; Funderburg, Nicholas et al. (2018) Soluble Urokinase Plasminogen Activator Receptor (suPAR) is predictive of Non-AIDS Events during Antiretroviral Therapy-mediated Viral Suppression. Clin Infect Dis :
MacDuffie, Katherine E; Brown, Gregory G; McKenna, Benjamin S et al. (2018) Effects of HIV Infection, methamphetamine dependence and age on cortical thickness, area and volume. Neuroimage Clin 20:1044-1052
Lin, Timothy C; Dijkstra, Maartje; De Bree, Godelieve J et al. (2018) Brief Report: The Amsterdam Symptom and Risk-Based Score Predicts for Acute HIV Infection in Men Who Have Sex With Men in San Diego. J Acquir Immune Defic Syndr 79:e52-e55

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