Mortality from infectious diseases remains a leading cause of death worldwide, making the development of new vaccines an important priority of biomedical research. Immunologic memory is a cardinal feature of adaptive immunity and an important goal of vaccination strategies. Traditional vaccination strategies are very effective at generating neutralizing antibodies against bacteria and viruses. However, a vaccine capable of generating robust T lymphocyte memory is still beyond our research, due, in part, to an incomplete understanding of how lymphocyte fates are specified. In this grant application, we propose to study the role of proteasome degradation activity in controlling this process.

Public Health Relevance

T lymphocytes are cells of the immune system that provide protection against infections. Vaccines generate different types of protective T lymphocytes. Our goal is to test new strategies that may improve vaccine efficacy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI129973-04
Application #
10066260
Study Section
Immunity and Host Defense (IHD)
Program Officer
Kelly, Halonna R
Project Start
2017-12-01
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
4
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093