Public Health Relevance

The Bioinformatics Core represents a new initiative for this renewal of the Center grant, taking the place of the Expression Profiling (Affyrrietrix) 'Core facility, which is now self-sustaining. The proposed Bioinformatics Core will facilitate the use of massively parallel sequencing (MPS) techniques, by providing neuroscientists with a dedicated bioinformatician. This Core will also serve as a repository of expertise for NINDS-funded and other UNC neuroscience faculty, particularly with regard to the design of MPS experiments, analysis of data, and use of existing MPS infrastructure at UNC-Chapel Hill. Since this level of bioinformatics support is also needed by neuroscientists in the Carolina Institute for Developmental Disabilities (ClOD), this Core will jointly be supported (50:50) by this NINDS Center grant and by ClOD.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
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Special Emphasis Panel (ZNS1)
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University of North Carolina Chapel Hill
Chapel Hill
United States
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Song, Liujiang; Llanga, Telmo; Conatser, Laura M et al. (2018) Serotype survey of AAV gene delivery via subconjunctival injection in mice. Gene Ther 25:402-414
Zhang, Jing; Wu, Tao; Simon, Jeremy et al. (2018) VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science 361:290-295
Boyer, Nicholas P; Monkiewicz, Caroline; Menon, Shalini et al. (2018) Mammalian TRIM67 Functions in Brain Development and Behavior. eNeuro 5:
Sidorov, Michael S; Judson, Matthew C; Kim, Hyojin et al. (2018) Enhanced Operant Extinction and Prefrontal Excitability in a Mouse Model of Angelman Syndrome. J Neurosci 38:2671-2682
Crowther, Andrew J; Lim, Szu-Aun; Asrican, Brent et al. (2018) An Adeno-Associated Virus-Based Toolkit for Preferential Targeting and Manipulating Quiescent Neural Stem Cells in the Adult Hippocampus. Stem Cell Reports 10:1146-1159
Allard, Denise E; Wang, Yan; Li, Jian Joel et al. (2018) Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment. J Clin Invest 128:4727-4741
Yeh, Chia-Yu; Asrican, Brent; Moss, Jonathan et al. (2018) Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways. Neuron 99:493-510.e4
Thaxton, Courtney; Kloth, Alexander D; Clark, Ellen P et al. (2018) Common Pathophysiology in Multiple Mouse Models of Pitt-Hopkins Syndrome. J Neurosci 38:918-936
Trzeciakiewicz, Hanna; Tseng, Jui-Heng; Wander, Connor M et al. (2017) A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Sci Rep 7:44102
Schmidt, Stephen L; Dorsett, Christopher R; Iyengar, Apoorva K et al. (2017) Interaction of Intrinsic and Synaptic Currents Mediate Network Resonance Driven by Layer V Pyramidal Cells. Cereb Cortex 27:4396-4410

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