Abstract

The aim of the Monoclonal Antibody Core is to generate mouse and rat monoclonal antibodies against proteins studied by NINDS investigators at JHU SOM. Antibodies are central for the analysis of protein function, and ongoing studies by the Primary Center Investigators and other NINDS-funded investigators at the JHU SOM have been severely limited by the availability of reliable quantities of unique mono-specific antibodies. The monoclonal facility will develop new antibodies with enhanced selectivity, providing a much-needed resource to the Center's primary investigators and also other NINDS-funded scientists at JHU SOM. No such facility currently exists at JHU SOM.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS050274-02
Application #
7312839
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
2
Fiscal Year
2006
Total Cost
$232,262
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Kajstura, Tymoteusz J; Dougherty, Sarah E; Linden, David J (2018) Serotonin axons in the neocortex of the adult female mouse regrow after traumatic brain injury. J Neurosci Res 96:512-526
Babola, Travis A; Li, Sally; Gribizis, Alexandra et al. (2018) Homeostatic Control of Spontaneous Activity in the Developing Auditory System. Neuron 99:511-524.e5
Dresselhaus, Erica C; Boersma, Matthew C H; Meffert, Mollie K (2018) Targeting of NF-?B to Dendritic Spines Is Required for Synaptic Signaling and Spine Development. J Neurosci 38:4093-4103
Larson, Valerie A; Mironova, Yevgeniya; Vanderpool, Kimberly G et al. (2018) Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility. Elife 7:
Jiang, Zheng; Yue, Wendy W S; Chen, Lujing et al. (2018) Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells. Cell 175:652-664.e12
Hughes, Ethan G; Orthmann-Murphy, Jennifer L; Langseth, Abraham J et al. (2018) Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. Nat Neurosci 21:696-706
Minamisawa, Genki; Kwon, Sung Eun; Chevée, Maxime et al. (2018) A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices. Cell Rep 23:2718-2731.e6
Zhang, Ke; Daigle, J Gavin; Cunningham, Kathleen M et al. (2018) Stress Granule Assembly Disrupts Nucleocytoplasmic Transport. Cell 173:958-971.e17
Chevée, Maxime; Robertson, Johanna De Jong; Cannon, Gabrielle Heather et al. (2018) Variation in Activity State, Axonal Projection, and Position Define the Transcriptional Identity of Individual Neocortical Projection Neurons. Cell Rep 22:441-455
Chen, Chih-Ming; Orefice, Lauren L; Chiu, Shu-Ling et al. (2017) Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci U S A 114:E619-E628

Showing the most recent 10 out of 83 publications