The administration of the Center Core will be distributed into three parts: Administrative Core, ImagingCores, and a Steering Committee. The Administrative Core will be managed by a Core Advisor who will beassisted by an administrative staff (see Chart on next page). The Core Advisor (22% effort) will be in chargeof equipment purchases and negotiating prices with vendors (especially where multiple purchases may enableprice reductions), managing the administrative staff, maintaining an inventory of core equipment andsupplies, scheduling regular meetings of the Steering Committee, and serving as liaison between the SteeringCommittee and the Core Directors. He will also be responsible for overseeing the system improvement projects,coordinating activities with our corporate partner and consultants, and organizing and completing theannual reports to NIH.Dr. Hockberger, Director of the 2P Imaging Cores in Physiology and consultant on the 2P cores in Pediatricsand Neurology, has agreed to serve as the Core Advisor. He has been active in the field of optical physiologyfor 25 years, and he has made seminal contributions related to dendritic Ca2+ signaling, the role of differentialadhesion in neuronal migration and pathfinding, and the sources and remedies of phototoxicity during livecell microscopy. He has been responsible for developing imaging resources (including CCD-based and 2Pimaging) at NU, Loyola University (Chicago), University of Erlangen (Germany), and the University of Bonn(Germany). He has been an active participant in the International Society for Optical Engineers (SPIE) for thepast 12 yrs, and he has been an invited speaker at numerous national and international symposia. At NU, hehas taken a leading role in the education of graduate students and postdocs on the quantitative aspects ofbiological imaging. Since 1992, he has directed a graduate course (IGP 415: Biological Imaging: Principles andApplications) that teaches the theory and practice of quantitative image analysis in the life sciences.Each imaging core will be managed by a Core Director. We have identified appropriate faculty who haveagreed to serve as Core Directors (see Chart), and their effort (5%) will be contributed by their respective departments.Directors will be responsible for oversight of the core, advising users on policies within the core,and keeping track of core usage. Each Director will have technical support to assist in running the day to dayactivities of the core (see Technical support, below).Oversight of the Center Core will be the responsibility of a Steering Committee comprised of the PI,senior faculty representing the various departments involved in this proposal, and the Core Advisor(ex officio). Dr. Surmeier (PI) has been the driving force behind the creation of the 2P imaging cores in
| Banala, Sambashiva; Arvin, Matthew C; Bannon, Nicholas M et al. (2018) Photoactivatable drugs for nicotinic optopharmacology. Nat Methods 15:347-350 |
| Sebel, Luke E; Graves, Steven M; Chan, C Savio et al. (2017) Haloperidol Selectively Remodels Striatal Indirect Pathway Circuits. Neuropsychopharmacology 42:963-973 |
| Vanorny, Dallas A; Mayo, Kelly E (2017) The role of Notch signaling in the mammalian ovary. Reproduction 153:R187-R204 |
| Genç, Bar??; Jara, Javier H; Schultz, Megan C et al. (2016) Absence of UCHL 1 function leads to selective motor neuropathy. Ann Clin Transl Neurol 3:331-45 |
| Flourakis, Matthieu; Kula-Eversole, Elzbieta; Hutchison, Alan L et al. (2015) A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Cell 162:836-48 |
| Inayat, Samsoon; Barchini, Jad; Chen, Hui et al. (2015) Neurons in the most superficial lamina of the mouse superior colliculus are highly selective for stimulus direction. J Neurosci 35:7992-8003 |
| Chu, Hong-Yuan; Atherton, Jeremy F; Wokosin, David et al. (2015) Heterosynaptic regulation of external globus pallidus inputs to the subthalamic nucleus by the motor cortex. Neuron 85:364-76 |
| Sanchez-Padilla, Javier; Guzman, Jaime N; Ilijic, Ema et al. (2014) Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase. Nat Neurosci 17:832-40 |
| Menelaou, Evdokia; VanDunk, Cassandra; McLean, David L (2014) Differences in the morphology of spinal V2a neurons reflect their recruitment order during swimming in larval zebrafish. J Comp Neurol 522:1232-48 |
| Vanorny, Dallas A; Prasasya, Rexxi D; Chalpe, Abha J et al. (2014) Notch signaling regulates ovarian follicle formation and coordinates follicular growth. Mol Endocrinol 28:499-511 |
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