The mission of the OUHSC Baboon Research Resource is to provide resources that support biomedical and behavioral research requiring the baboon as the animal model. A vital part of this mission is the production of Specific Pathogen Free (SPF) baboons. Unique in the world, the OUHSC SPF baboon program is poised to provide an indispensable nonhuman primate resource for biomedical research. The goal of this program is to complete development of an active, self-supporting breeding colony of baboons that are free of all five known baboon herpes viruses, four retroviruses, as well as a number of additional viruses and parasites. The developing program is already providing some SPF baboons to NIH-funded biomedical research programs, but cannot meet the demand for these unique animals. To complete development of this national resource we will recruit an additional 150 infants over five years into the SPF program. The genetic diversity of the colony will be assessed and monitored to maximize its genetic diversity. During this final phase of colony development, we will continue to provide 20-30 SPF baboons per year to NIH-funded research programs. To keep the colony outbred genetic testing will be performed and evaluated. Several research projects will also be supported by this program with the aim of improving the resource. The long term objective is for the SPF baboon colony to be a stable, self-sustaining breeding colony that produces ~100 SPF baboons/year for use in NIH-funded biomedical research.

Public Health Relevance

Certain infectious agents can alter experimental results when they infect an animal used in research. Use of Specific Pathogen Free animals that are free of certain pathogens are preferred in biomedical research to avoid this problem. The SPF baboon program in Oklahoma is the only source for SPF baboons in the world and this grant will provide support for the development and maintenance of this colony.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
Application #
Study Section
Special Emphasis Panel (ZTR1-CM-6 (01))
Program Officer
Contreras, Miguel A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Oklahoma Health Sciences Center
Schools of Medicine
Oklahoma City
United States
Zip Code
Reichard, Mason V; Thomas, Jennifer E; Chavez-Suarez, Maria et al. (2017) Pilot Study to Assess the Efficacy of Ivermectin and Fenbendazole for Treating Captive-Born Olive Baboons (Papio anubis) Coinfected with Strongyloides fülleborni and Trichuris trichiura. J Am Assoc Lab Anim Sci 56:52-56
Iwase, Hayato; Liu, Hong; Li, Tao et al. (2017) Therapeutic regulation of systemic inflammation in xenograft recipients. Xenotransplantation 24:
Iwase, Hayato; Liu, Hong; Schmelzer, Eva et al. (2017) Transplantation of hepatocytes from genetically engineered pigs into baboons. Xenotransplantation 24:
Iwase, Hayato; Ekser, Burcin; Hara, Hidetaka et al. (2016) Thyroid hormone: relevance to xenotransplantation. Xenotransplantation 23:293-9
Ezzelarab, Mohamed B; Ekser, Burcin; Azimzadeh, Agnes et al. (2015) Systemic inflammation in xenograft recipients precedes activation of coagulation. Xenotransplantation 22:32-47
Nguyen, Annalee W; Wagner, Ellen K; Laber, Joshua R et al. (2015) A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough. Sci Transl Med 7:316ra195
Iwase, H; Ekser, B; Satyananda, V et al. (2015) Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs. Transpl Immunol 32:99-108
Iwase, Hayato; Ekser, Burcin; Zhou, Huidong et al. (2015) Further evidence for sustained systemic inflammation in xenograft recipients (SIXR). Xenotransplantation 22:399-405
Warfel, Jason M; Merkel, Tod J (2014) Reply to Domenech de Cellès et al.: Infection and transmission of pertussis in the baboon model. Proc Natl Acad Sci U S A 111:E718
Karmakar, Souvik; Zhang, Weidong; Ahmad, Gul et al. (2014) Use of an Sm-p80-based therapeutic vaccine to kill established adult schistosome parasites in chronically infected baboons. J Infect Dis 209:1929-40

Showing the most recent 10 out of 27 publications