The OUHSC Baboon Resource Program continues to serves as a national source of baboons for NIH supported biomedical and behavioral research. Over the last four years we have provided 582 baboons to 23 Institutions outside the University of Oklahoma Health Sciences Center. We have also provided 110 baboons over the last four years for the developing OUHSC Baboon Specific Pathogen Free (SPF) baboon program. This SPF colony is unique and is the only known NIH baboon colony that is negative for 13 endogenous viruses including all five known baboon herpes viruses, four retroviruses, plus four other baboon viruses and the most common baboon parasites. We continue to make significant progress toward self-sufficiency as the program income provides almost 50% of the support of the baboon research resource program. Significant progress has been made in our infrastructure with the completion of the new state of the art 6.5 million dollar, 18,000 square foot Baboon SPF building. Our collaboration with the Oklahoma State University Center for Veterinary Health Sciences (OSUHSC) (College of Veterinary Medicine) continues to produce significant research resource related research. This application has a significantly stronger behavioral and genetic program with the addition of a PhD level genetic behaviorist (John Ely, PhD). We are now performing in house viral diagnostics with the addition of a full time PhD level Virologist (James Papin, PhD). Recently we have added a full time Veterinary Immunologist to our Comparative Medicine Faculty (Sunil Joshi, DVM, PhD). These three full time research and diagnostic faculty significantly strengthens our diagnostic and research expertise in behavior, genonomics, virology, and immunology. The OUHSC Baboon Research Resource program continues to attract more veterinary student preceptors. Over the last four years we have had veterinary student preceptors and visiting summer students from seven veterinary schools. We continue to host a summer visit and tour for NIH T 35 students from, Oklahoma State University, University of Missouri, and Kansas State University. The OUHSC Baboon Research Resource continues to serve as a national source for biomedical, and behavior research.

Public Health Relevance

The OUHSC Baboon Research Resource is one of two NIH baboon programs supported by the NIH. We support both conventional and specific pathogen free baboons to NIH supported investigators nationally. The baboon ranks third among the number of non-human primates used in biomedical and behavioral research in the United States. An OVID Medline search revealed that over the last five years 1,028 scientific publications utilized the baboons as the animal model.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
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Study Section
Special Emphasis Panel (ZTR1-CM-6 (01))
Program Officer
Harding, John D
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University of Oklahoma Health Sciences Center
Schools of Medicine
Oklahoma City
United States
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Tobiasz, Ana M; Duncan, Jose R; Bursac, Zoran et al. (2018) The Effect of Prenatal Alcohol Exposure on Fetal Growth and Cardiovascular Parameters in a Baboon Model of Pregnancy. Reprod Sci 25:1116-1123
Gurung, Sunam; Preno, Alisha N; Dubaut, Jamie P et al. (2018) Translational Model of Zika Virus Disease in Baboons. J Virol :
Eberle, R; Jones-Engel, L (2017) Understanding Primate Herpesviruses. J Emerg Dis Virol 3:
Faller, Douglas V; Castaneda, Serguei A; Zhou, Daohong et al. (2017) An oral HemokineTM, ?-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo. Blood Cells Mol Dis 63:1-8
Eberle, R; Black, Darla H (2017) Sequence of the ateline alphaherpesvirus 1 (HVA1) genome. Arch Virol 162:1423-1425
Reichard, Mason V; Thomas, Jennifer E; Chavez-Suarez, Maria et al. (2017) Pilot Study to Assess the Efficacy of Ivermectin and Fenbendazole for Treating Captive-Born Olive Baboons (Papio anubis) Coinfected with Strongyloides f├╝lleborni and Trichuris trichiura. J Am Assoc Lab Anim Sci 56:52-56
Iwase, Hayato; Liu, Hong; Li, Tao et al. (2017) Therapeutic regulation of systemic inflammation in xenograft recipients. Xenotransplantation 24:
Eberle, R; Maxwell, L K; Nicholson, S et al. (2017) Genome sequence variation among isolates of monkey B virus (Macacine alphaherpesvirus 1) from captive macaques. Virology 508:26-35
Seleverstov, Olga; Tobiasz, Ana; Jackson, J Scott et al. (2017) Maternal alcohol exposure during mid-pregnancy dilates fetal cerebral arteries via endocannabinoid receptors. Alcohol 61:51-61
Iwase, Hayato; Liu, Hong; Schmelzer, Eva et al. (2017) Transplantation of hepatocytes from genetically engineered pigs into baboons. Xenotransplantation 24:

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