The Bloomington Drosophila Stock Center (BDSC) supports a large, worldwide community of scientists using the insect Drosophila melanogaster as a model organism for biomedical experimentation. The goals of the BDSC are to provide a collection of documented living stocks of broad value to current research, to preserve documented strains with clear future value, and to provide information and support services that promote maximal exploitation of these materials. These goals facilitate research by providing universal and rapid access to the most generally useful stocks, by preserving specialty genotypes with exceptional characteristics, and by providing information that helps researchers identify stocks appropriate to their needs. Drosophila is used extensively in studies of biological processes relevant to human health and investigations of molecular mechanisms underlying disease, because genetic technologies available to Drosophila researchers are among the most sophisticated in any multicellular organism. As the most comprehensive source of stocks for genetic experimentation with Drosophila, the BDSC is central to the success of many research projects including a large number of NIH grants. The first specific aim of this proposal is to continue acquiring, maintaining and distributing Drosophila strains and to continue developing associated information resources to meet the research needs of Drosophila scientists while maintaining and promoting excellent user support. Key to this aim is the administration and advancement of the highly successful cost recovery program that finances operational expenses from user fees. Consequently, the proposal focuses on support and development of the core management team as the most effective way to leverage the investment of NIH resources. The second specific aim is to undertake research to increase the utility of a subset of BDSC stocks which have been preserved for their distinctive mutant phenotypes. The work will experimentally map mutations in these stocks to specific transcription units in the genome sequence and will substantially increase the usefulness and relevance of the stocks to researchers investigating the functional significance of molecularly defined genes.

Public Health Relevance

The Bloomington Drosophila Stock Center is the U.S. repository and distribution center for genetically characterized strains of Drosophila melanogaster, an insect used in thousands of laboratories worldwide both to investigate fundamental biological processes and to understand cellular mechanisms related to human diseases.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
1P40OD018537-01
Application #
8742627
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Harding, John D
Project Start
2014-08-01
Project End
2019-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Indiana University Bloomington
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Sriskanthadevan-Pirahas, Shrivani; Deshpande, Rujuta; Lee, Byoungchun et al. (2018) Ras/ERK-signalling promotes tRNA synthesis and growth via the RNA polymerase III repressor Maf1 in Drosophila. PLoS Genet 14:e1007202
Walther, Rhian F; Burki, Mubarik; Pinal, Noelia et al. (2018) Rap1, Canoe and Mbt cooperate with Bazooka to promote zonula adherens assembly in the fly photoreceptor. J Cell Sci 131:
Negreiros, Erika; Herszterg, Sophie; Kang, Kyung-Hwa et al. (2018) N-linked glycosylation restricts the function of Short gastrulation to bind and shuttle BMPs. Development 145:
Hall, Hana; Ma, Jingqun; Shekhar, Sudhanshu et al. (2018) Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors. BMC Neurosci 19:43
Zlatic, Stephanie A; Vrailas-Mortimer, Alysia; Gokhale, Avanti et al. (2018) Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees. Cell Syst 6:368-380.e6
Carvalho, Lara; Patricio, Pedro; Ponte, Susana et al. (2018) Occluding junctions as novel regulators of tissue mechanics during wound repair. J Cell Biol 217:4267-4283
Creamer, Matthew S; Mano, Omer; Clark, Damon A (2018) Visual Control of Walking Speed in Drosophila. Neuron :
Kamareddine, Layla; Robins, William P; Berkey, Cristin D et al. (2018) The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism. Cell Metab 28:449-462.e5
Fernández-Espartero, Cecilia H; Rizzo, Alberto; Fulford, Alexander D et al. (2018) Prp8 regulates oncogene-induced hyperplastic growth in Drosophila. Development 145:
Weiner, Alexis T; Seebold, Dylan Y; Michael, Nick L et al. (2018) Identification of Proteins Required for Precise Positioning of Apc2 in Dendrites. G3 (Bethesda) 8:1841-1853

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