The overall objective of this renewal application is to continue to produce approximately 200 characterized baboons per year for biomedical research in this country. Four subspecies of baboons are included in this program. The primary breeding colony is Papio c. anubis with small breeding groups of Papio c. cynocephalus, Papio c. hamadryas and Papio c. papio. Studies on primate husbandry and medicine emphasizing the development of large scale cost effective techniques will continue. Baboons with unique characteristics will continue to be selected as models for biomedical research. The colony will continue to be managed from a genetic perspective using genetic markers and computer programs developed specifically for this purpose. Reproductive efficiency will be improved employing demographic and cost estimation methods that involve computer simulation. Growth and development data will continue to be collected in order to better define this animal model.
| Hubbard, G B; Mone, J P; Allan, J S et al. (1993) Spontaneously generated non-Hodgkin's lymphoma in twenty-seven simian T-cell leukemia virus type 1 antibody-positive baboons (Papio species). Lab Anim Sci 43:301-9 |
| Hubbard, G B; Soike, K F; Butler, T M et al. (1992) An encephalomyocarditis virus epizootic in a baboon colony. Lab Anim Sci 42:233-9 |
| Dyke, B; Williams-Blangero, S; Dyer, T D et al. (1990) Use of isozymes in genetic management of nonhuman primate colonies. Prog Clin Biol Res 344:563-74 |
| Levin, J L; Hilliard, J K; Lipper, S L et al. (1988) A naturally occurring epizootic of simian agent 8 in the baboon. Lab Anim Sci 38:394-7 |
| Butler, T M; Gleiser, C A; Bernal, J C et al. (1988) Case of disseminated African histoplasmosis in a baboon. J Med Primatol 17:153-61 |
| Cheng, M L; Kuehl, T J; Vandeberg, J L (1987) Pregnancy-associated esterase in sera of baboons. J Exp Zool 241:113-21 |
| Goodwin, W J; Haines, R J; Bernal, J C (1987) Tetanus in baboons of a corral breeding colony. Lab Anim Sci 37:231-2 |
| Stone, W H; Treichel, R C; VandeBerg, J L (1987) Genetic significance of some common primate models in biomedical research. Prog Clin Biol Res 229:73-93 |
| Glassman, D M; Coelho Jr, A M (1987) Principal components analysis of physical growth in savannah baboons. Am J Phys Anthropol 72:59-66 |
| Dyke, B; Gage, T B; VandeBerg, J L et al. (1987) Decision making in genetic management of primate breeding colonies. Genetica 73:137-44 |
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