This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regarding AIDS DESCRIPTION (provided by applicant): The use of pig-tailed macaques (Macaca nemestrina) in all areas of medical research has increased to the point that demand exceeds supply and increased research activity in bioterrorism will undoubtedly increase the demand for nonhuman primates in the near future. The resulting increased prices and increased delays in procuring monkeys hinder the ability to conduct funded research. Researchers in many fields have experienced similar disruptions in their ability to conduct research. The primary objective of this application is to develop a new national resource that will supply SPF pig-tailed macaques to researchers across the country. The proposed resource-related research would also further the usefulness of the pig-tailed macaque as a research model through the development of key reagents for research in the immunology. Pig-tailed macaques are used in a wide variety of medical research. AIDS research is the newest demand on the supply of pig-tailed macaques, but in the last 5 years, 75% of published studies with pig-tailed macaques have been in non-AIDS research areas. As demand for pig-tailed macaques has increased, paradoxically, commercial breeding sources have declined production. Covance, disbanded their pig-tailed macaque breeding program, and LABS of Virginia reduced their breeding stock by one third. The Yerkes and Washington National Primate Research Centers (WaNPRC)/Tulane NRPRC and the New Iberia Primate Research Center are the only facilities with a sizable pig-tailed macaque breeding program. Despite recent increases in their breeding capacity, officials at WaNPRC indicate that they will not be able to meet the current and expected demand for pig-tailed macaques in research. Funding of this application will allow the continued expansion of an existing colony to approximately 125 breeding-age females yielding enough animals to maintain the breeding stock and produce approximately 62 offspring each year. With a colony this size, 50% of the male offspring would be made available for sale at market prices to researchers outside of the Johns Hopkins University. Demand for pig-tailed macaques from NIH funded grants already exceeds current supplies. New national research infrastructure must be developed to help meet existing and future research demands.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
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National Center for Research Resources Initial Review Group (RIRG)
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Johns Hopkins University
Veterinary Sciences
Schools of Medicine
United States
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Hosseini, Iraj; Gama, Lucio; Mac Gabhann, Feilim (2015) Multiplexed Component Analysis to Identify Genes Contributing to the Immune Response during Acute SIV Infection. PLoS One 10:e0126843
Freeman, Zachary T; Krall, Caroline; Rice, Kelly A et al. (2015) Severity and Distribution of Wounds in Rhesus Macaques (Macaca mulatta) Correlate with Observed Self-Injurious Behavior. J Am Assoc Lab Anim Sci 54:516-20
Freeman, Z T; Rice, K A; Soto, P L et al. (2015) Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior. Transl Psychiatry 5:e567
Ebenezer, Gigi J; McArthur, Justin C; Polydefkis, Michael et al. (2012) SIV-induced impairment of neurovascular repair: a potential role for VEGF. J Neurovirol 18:222-30
Queen, Suzanne E; Mears, Brian M; Kelly, Kathleen M et al. (2011) Replication-competent simian immunodeficiency virus (SIV) Gag escape mutations archived in latent reservoirs during antiretroviral treatment of SIV-infected macaques. J Virol 85:9167-75
Fernandez, Caroline S; Reece, Jeanette C; Saepuloh, Uus et al. (2011) Screening and confirmatory testing of MHC class I alleles in pig-tailed macaques. Immunogenetics 63:511-21
Dietrich, Elizabeth A; Brennan, Greg; Ferguson, Betsy et al. (2011) Variable prevalence and functional diversity of the antiretroviral restriction factor TRIMCyp in Macaca fascicularis. J Virol 85:9956-63
Bimber, Benjamin N; Dudley, Dawn M; Lauck, Michael et al. (2010) Whole-genome characterization of human and simian immunodeficiency virus intrahost diversity by ultradeep pyrosequencing. J Virol 84:12087-92
Bimber, Benjamin N; Burwitz, Benjamin J; O'Connor, Shelby et al. (2009) Ultradeep pyrosequencing detects complex patterns of CD8+ T-lymphocyte escape in simian immunodeficiency virus-infected macaques. J Virol 83:8247-53
O'Leary, Claire E; Wiseman, Roger W; Karl, Julie A et al. (2009) Identification of novel MHC class I sequences in pig-tailed macaques by amplicon pyrosequencing and full-length cDNA cloning and sequencing. Immunogenetics 61:689-701

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