The mission for the NIH BioMEMS Resource Center (BMRC) is to bridge between microelectromechanicai systems (MEMS) and biomedical community to provide powerful microtechnologies to biomedical and clinical investigators. At its inception, the focus of the BMRC research was on the development of microfluidic chips for cell sorting, especially for fractionation of blood into its key components as well as the creation of living single cell arrays. In 2008, BMRC was renewed to expand its research portfolio to include rare cells with tremendous clinical potential, and more complex dynamic tissue microarrays. As we lool

Public Health Relevance

MRC continues to represent a significant potential for biomedical advances through its mission to develop and disseminate innovative microtechnologies with a broad range of applications varying from diagnostics, therapeutics, biomarker discovery, drug screening to disease models.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Biotechnology Resource Grants (P41)
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Special Emphasis Panel (ZEB1)
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Hunziker, Rosemarie
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Massachusetts General Hospital
United States
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Kang, Young Bok Abraham; Eo, Jinsu; Mert, Safak et al. (2018) Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes. Sci Rep 8:8951
Jorfi, Mehdi; D'Avanzo, Carla; Kim, Doo Yeon et al. (2018) Three-Dimensional Models of the Human Brain Development and Diseases. Adv Healthc Mater 7:
Otawara, Masayuki; Roushan, Maedeh; Wang, Xiao et al. (2018) Microfluidic Assay Measures Increased Neutrophil Extracellular Traps Circulating in Blood after Burn Injuries. Sci Rep 8:16983
Ellett, Felix; Jorgensen, Julianne; Marand, Anika L et al. (2018) Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay. Nat Biomed Eng 2:207-214
Huang, Haishui; Yarmush, Martin L; Usta, O Berk (2018) Long-term deep-supercooling of large-volume water and red cell suspensions via surface sealing with immiscible liquids. Nat Commun 9:3201
Mutlu, Baris R; Edd, Jon F; Toner, Mehmet (2018) Oscillatory inertial focusing in infinite microchannels. Proc Natl Acad Sci U S A 115:7682-7687
Shrirao, Anil B; Fritz, Zachary; Novik, Eric M et al. (2018) Microfluidic flow cytometry: The role of microfabrication methodologies, performance and functional specification. Technology (Singap World Sci) 6:1-23
ReƔtegui, Eduardo; van der Vos, Kristan E; Lai, Charles P et al. (2018) Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Nat Commun 9:175
Gokduman, Kurtulus; Bestepe, Furkan; Li, Lei et al. (2018) Dose-, treatment- and time-dependent toxicity of superparamagnetic iron oxide nanoparticles on primary rat hepatocytes. Nanomedicine (Lond) 13:1267-1284
Muldur, Sinan; Marand, Anika L; Ellett, Felix et al. (2018) Measuring spontaneous neutrophil motility signatures from a drop of blood using microfluidics. Methods Cell Biol 147:93-107

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