The mission for the NIH BioMEMS Resource Center (BMRC) is to bridge between microelectromechanicai systems (MEMS) and biomedical community to provide powerful microtechnologies to biomedical and clinical investigators. At its inception, the focus of the BMRC research was on the development of microfluidic chips for cell sorting, especially for fractionation of blood into its key components as well as the creation of living single cell arrays. In 2008, BMRC was renewed to expand its research portfolio to include rare cells with tremendous clinical potential, and more complex dynamic tissue microarrays. As we lool

Public Health Relevance

MRC continues to represent a significant potential for biomedical advances through its mission to develop and disseminate innovative microtechnologies with a broad range of applications varying from diagnostics, therapeutics, biomarker discovery, drug screening to disease models.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
2P41EB002503-11
Application #
8609426
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Hunziker, Rosemarie
Project Start
2004-04-01
Project End
2019-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Wang, Xiao; Jodoin, Emily; Jorgensen, Julianne et al. (2018) Progressive mechanical confinement of chemotactic neutrophils induces arrest, oscillations, and retrotaxis. J Leukoc Biol 104:1253-1261
Weng, Lindong; Stott, Shannon L; Toner, Mehmet (2018) Molecular Dynamics at the Interface between Ice and Poly(vinyl alcohol) and Ice Recrystallization Inhibition. Langmuir 34:5116-5123
Jorfi, Mehdi; D'Avanzo, Carla; Tanzi, Rudolph E et al. (2018) Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease. Sci Rep 8:2450
Boneschansker, Leo; Jorgensen, Julianne; Ellett, Felix et al. (2018) Convergent and Divergent Migratory Patterns of Human Neutrophils inside Microfluidic Mazes. Sci Rep 8:1887
Shrirao, Anil B; Kung, Frank H; Omelchenko, Anton et al. (2018) Microfluidic platforms for the study of neuronal injury in vitro. Biotechnol Bioeng 115:815-830
Kang, Young Bok Abraham; Eo, Jinsu; Mert, Safak et al. (2018) Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes. Sci Rep 8:8951
Jorfi, Mehdi; D'Avanzo, Carla; Kim, Doo Yeon et al. (2018) Three-Dimensional Models of the Human Brain Development and Diseases. Adv Healthc Mater 7:
Otawara, Masayuki; Roushan, Maedeh; Wang, Xiao et al. (2018) Microfluidic Assay Measures Increased Neutrophil Extracellular Traps Circulating in Blood after Burn Injuries. Sci Rep 8:16983
Ellett, Felix; Jorgensen, Julianne; Marand, Anika L et al. (2018) Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay. Nat Biomed Eng 2:207-214
Huang, Haishui; Yarmush, Martin L; Usta, O Berk (2018) Long-term deep-supercooling of large-volume water and red cell suspensions via surface sealing with immiscible liquids. Nat Commun 9:3201

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