A shared 900 MHz NMR facility will be established for the Central California area, to be housed in the new QB3 Institute (Institute for Quantitative Biomedical Research) at the University of California Berkeley. The instrument will be available to investigators throughout the region. Specific proposals are included from investigators at UC Berkeley, Stanford, UC San Francisco, UC Davis, Lawrence Livermore National Lab and Genentech. Time on the instrument will be allocated to maximize its application to problems which challenge the limits of current NMR capability. Systems under study will include large viral and ribosomal RNAs, VS ribozyme, viral protein-RNA interactions, metalloprotein heine oxygenases, TNF ligand and receptor interactions, bacterial transcriptional activators, proteins studied inside cells, cytokines and their receptors, and proteins involved in DNA repair and their complexes. Support for carrying out state of the art spectroscopy, libraries of pulse sequences and their documentation, and general user guides will be provided by staff members in the facility. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
5P41GM068933-04
Application #
7086403
Study Section
Special Emphasis Panel (ZRG1-SSS-A (40))
Program Officer
Wehrle, Janna P
Project Start
2003-07-15
Project End
2008-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
4
Fiscal Year
2006
Total Cost
$250,164
Indirect Cost
Name
University of California Berkeley
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
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