Abstract

Overall Rationale for the Resource The overall rationale for the National Resource for the Mass Spectrometric Analysis of Biological Macromolecules is to develop instrumentation and methodology that facilitates biological and biomedical research;test and apply these developments on important problems of biomedical interest;disseminate our developments to the biomedical community at large;and train scientists in these advanced techniques. Our goal is to push the envelope in terms of sensitivity, accuracy and breadth of application, so that mass spectrometry can be applied more and more broadly for uncovering new biology and become an increasingly important facilitator of biomedical research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
9P41GM103314-39
Application #
8268768
Study Section
Special Emphasis Panel (ZRG1-BCMB-H (40))
Program Officer
Sheeley, Douglas
Project Start
1996-12-23
Project End
2013-02-28
Budget Start
2012-04-01
Budget End
2013-02-28
Support Year
39
Fiscal Year
2012
Total Cost
$1,469,053
Indirect Cost
$602,355

  Institution

Name
Rockefeller University
Department
Miscellaneous
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Delgado-Benito, Verónica; Rosen, Daniel B; Wang, Qiao et al. (2018) The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination. Mol Cell 72:636-649.e8
Jishage, Miki; Yu, Xiaodi; Shi, Yi et al. (2018) Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. Nat Struct Mol Biol 25:859-867
Kim, Seung Joong; Fernandez-Martinez, Javier; Nudelman, Ilona et al. (2018) Integrative structure and functional anatomy of a nuclear pore complex. Nature 555:475-482
Kleiner, Ralph E; Hang, Lisa E; Molloy, Kelly R et al. (2018) A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells. Cell Chem Biol 25:110-120.e3
Sanghai, Zahra Assur; Miller, Linamarie; Molloy, Kelly R et al. (2018) Modular assembly of the nucleolar pre-60S ribosomal subunit. Nature 556:126-129
Winczura, Kinga; Schmid, Manfred; Iasillo, Claudia et al. (2018) Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions. Cell Rep 22:44-58
Holden, Jennifer M; Koreny, Ludek; Obado, Samson et al. (2018) Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes. Mol Biol Cell 29:1100-1110
Taylor, Martin S; Altukhov, Ilya; Molloy, Kelly R et al. (2018) Dissection of affinity captured LINE-1 macromolecular complexes. Elife 7:
Chan, Ho Lam; Beckedorff, Felipe; Zhang, Yusheng et al. (2018) Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms. Nat Commun 9:3377
Schrank, Benjamin R; Aparicio, Tomas; Li, Yinyin et al. (2018) Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature 559:61-66

Showing the most recent 10 out of 64 publications