The project will develop a world-leading suite of experimental facilities for the life-science research community. With the focus on macromolecular crystallography (MX) and x-ray scattering, there will also be user programs in correlated MX and optical spectroscopy, and one in fluorescence imaging of metals in biological materials. The extraordinary brightness of NSLS-II will provide unprecedentedly small, bright, and well-collimated x-ray beams. To exploit these qualities, extra care will be exerted to provide the best quality crystal-diffraction and x-ray scattering data from the NSLS-II beams, and high levels of automation. Multiple experimental modes will be installed for x-ray scattering to investigate solutions, membranes, and tissues. We expect high success of the project, owed in part to the remarkable community of life-science researchers in the 400 mile-long corridor from Boston to Washington, all within driving distance of BNL, and to the solid record of productivity in structural biology having been provided this community during the lifetime of the NSLS.
Synchrotron x-ray sources provide the best possible structural information for biologists active in medical, and all other life-science, research. NSLS II will be the brightest source available when it comes into operation in 2015-16. This project wil provide the best possible experimental facilities to enable life scientists to employ the facility or their research.
|Peselis, Alla; Serganov, Alexander (2018) ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands. Nat Chem Biol 14:887-894|
|Dieck, Chelsea L; Tzoneva, Gannie; Forouhar, Farhad et al. (2018) Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell 34:136-147.e6|
|Maheshwari, Sweta; Shimokawa, Chizu; Rudzka, Katarzyna et al. (2018) Effects of copper occupancy on the conformational landscape of peptidylglycine ?-hydroxylating monooxygenase. Commun Biol 1:74|
|Ha, Byung Hak; Boggon, Titus J (2018) CDC42 binds PAK4 via an extended GTPase-effector interface. Proc Natl Acad Sci U S A 115:531-536|
|Peng, Yi; Cao, Shufen; Kiselar, Janna et al. (2018) A Metastable Contact and Structural Disorder in the Estrogen Receptor Transactivation Domain. Structure :|
|Chu, Nam; Salguero, Antonieta L; Liu, Albert Z et al. (2018) Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell 174:897-907.e14|
|Choi, Elliot H; Suh, Susie; Sander, Christopher L et al. (2018) Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet 27:2225-2243|
|Uchida, Masaki; McCoy, Kimberly; Fukuto, Masafumi et al. (2018) Modular Self-Assembly of Protein Cage Lattices for Multistep Catalysis. ACS Nano 12:942-953|
|Hvorecny, Kelli L; Bahl, Christopher D; Kitamura, Seiya et al. (2017) Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase. Structure 25:697-707.e4|
|Marmont, Lindsey S; Rich, Jacquelyn D; Whitney, John C et al. (2017) Oligomeric lipoprotein PelC guides Pel polysaccharide export across the outer membrane of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 114:2892-2897|
Showing the most recent 10 out of 217 publications