Abstract

Provide clinical researchers with a facility and personnel capable of developing basic separation methods, and identifying and/or synthesizing organic compounds isolated from physiological fluids. This facility would be built upon the foundation provided by the two existing mass spectrometry laboratories and both would be upgraded to handle the additional sample load. The facility would be a training and educational center for medical researchers interested in applying mass spectrometry to clinical problems.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001152-07
Application #
3103768
Study Section
(BET)
Project Start
1980-07-01
Project End
1989-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
7
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Wolucka, B A; McNeil, M R; Kalbe, L et al. (1993) Isolation and characterization of a novel glucuronosyl diacylglycerol from Mycobacterium smegmatis. Biochim Biophys Acta 1170:131-6
Rohl, C A; Scholtz, J M; York, E J et al. (1992) Kinetics of amide proton exchange in helical peptides of varying chain lengths. Interpretation by the Lifson-Roig equation. Biochemistry 31:1263-9
Friel, J K; Naake Jr, V L; Miller, L V et al. (1992) The analysis of stable isotopes in urine to determine the fractional absorption of zinc. Am J Clin Nutr 55:473-7
Cetin, I; Fennessey, P V; Quick Jr, A N et al. (1991) Glycine turnover and oxidation and hepatic serine synthesis from glycine in fetal lambs. Am J Physiol 260:E371-8
Tjoa, S; Fennessey, P (1991) The identification of trimethylamine excess in man: quantitative analysis and biochemical origins. Anal Biochem 197:77-82
Scholtz, J M; Qian, H; York, E J et al. (1991) Parameters of helix-coil transition theory for alanine-based peptides of varying chain lengths in water. Biopolymers 31:1463-70
Morrison Jr, J E; Matthews, D; Washington, R et al. (1991) Phenol motor point blocks in children: plasma concentrations and cardiac dysrhythmias. Anesthesiology 75:359-62
Nusser, E; Banerjee, A; Gal, J (1991) Excavations in drug chirality: 1. Cyclothiazide. Chirality 3:2-13
Harrison, L M; Morrison, J E; Fennessey, P V (1991) Microtechnique for quantifying phenol in plasma by gas chromatography-mass spectrometry. Clin Chem 37:1739-42
Daffe, M; McNeil, M; Brennan, P J (1991) Novel type-specific lipooligosaccharides from Mycobacterium tuberculosis. Biochemistry 30:378-88

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