This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With NIH NCRR support, a workshop 'Advances in X-ray Scattering/ Diffraction Studies on Non-Crystalline Biological Systems' was given on October 15-16, 2005 in association with the 32nd Annual SSRL Users' Meeting. Over 50 external participants gathered to learn about the latest scientific results from solution x-ray scattering (speakers: D. Svergun, EMBL-Hamburg; S. Doniach, Stanford Univ.; A. Tardieu, CNRS, France), fiber (G. Stubbs, Vanderbilt Univ.) and lipid membrane (H. Huang, Rice Univ.) diffraction studies on biological macromolecules and large assemblies. Complemental aspects of solution x-ray scattering in virus research were presented by J.E. Johnson (Scripps Res. Inst.), and N. Yagi (SPring-8/JASRI, Japan) shared some of the highly exciting examples of the use of high-energy 3rd generation synchrotron facilities in these techniques. Software demonstration sessions by D. Svergun and W. Wriggers (U. Texas, Houston) were received enthusiastically. Three parallel sessions on experimental aspects were held at BL4-2. P. Liu gave demonstration of automated distance change, automated sample alignment and discussed other hardware aspects of the facility. M. Niebuhr demonstrated the special version of Blu-ICE adopted for BL4-2 beam line control and static SAXS/D data collection, and gave an overview of BL4-2 detector systems. H. Tsuruta covered viewing of sample handing devices and discussion on sample preparation and data collection simulation using an in-vacuum flow cell. Participants engaged in active discussion on a number of experimental and computational issues throughout the workshop.
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