This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.ABSTRACT We see swirls in Drosophila flight muscle mitochondria in response to oxidative stress. 3D tomography is needed to see their detailed structure. Specifically, we want to know whether there are single or multiple cristae involved in swirl formation, how the swirl shape relates to the shape of normal cristae in these mitochondria, and whether the swirl cristae are attached to the peripheral region of the inner membrane (i.e. whether there are crista junctions). In the previous reporting period, tisue blocks were received and sections were cut for HVEM tomography. Two single-tilt reconstructions were made.
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