This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The combined application of diffuse reflectance, intrinsic fluorescence and Raman spectroscopy will be applied to the study of breast cancer to determine feasibility of detection. Previous results obtained from Raman spectroscopy have allowed classification of tissue into normal, intraductal carcinoma, fiber cystic change and fiberadenoma with high sensitivity and specificity. in this feasibility study, spectral results from two additional modalities, reflectance and fluorescence will be combined with Raman to construct a diagnostic algorithm. Spectral will be collected from freshly excised specimens in the University Hospitals of Cleveland pathology suite within half an hour of excision during partial and whole mastectomy.
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