This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Rats are being fed special diet rich in ammonium oxalate to induce crystal/stone formation in their kidneys. They will undergo shock wave treatment and be followed to identify if lithotripsy induces further crystal formation secondary to tissue injury. In order to evaluate these effects, pathological studies will be conducted at different intervals. MR imaging with 2T magnet of crystals/stones would also corroborate with the hypothesis, allowing follow up of animals. We are currently identifying the best moment for shockwave and we have seen crystal deposition in the pathological analysis.
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