This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Keywords: CFD, spray dynamics, inhalation theraphy spray Abstract: A research project is proposed: 1) to study the deposition of airborne respirable nanoparticle in the respiratory tract in a 3-D numerical simulation of an anatomically realistic 17-generation lung bronchial tree model for a better understanding of the biological impacts, 2) to study the deposition of the inhalation therapy spray in the human lung airways track to find out the optimum medicinal aerosol size and spray dynamics for an efficient drug delivery to the lung surfaces. An understanding of the anatomy and morphometry of the airways and the lungs forms the first step in an examination of pulmonary aerosol deposition. Studies of the airways are becoming increasingly more detailed supporting efforts to provide more efficient delivery of inhaled medications and to understand the effects of inhaled pollutants. Particle diffusion within the human airways plays a critical role in aerosol therapy and inhalation toxicology. Particle deposition patterns in the carinal region area are highly affected by impinging gas flow fields. This has important implications for risk assessment programs and aerosol therapy protocols.
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