This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Keywords: cytoskeleton, molecular dynamics, actin, microtubules Abstract: All cells contain a complex network of filaments and proteins called the cytoskeleton. This system provides structure within the cell that is essential for cell motility and division, and is responsible for transport of materials, plus many other functions. There are three types of filaments that make up the cytoskeleton: actin filaments, intermediate filaments and microtubules, as well as a host of associated proteins. Understanding the function of these polymers and proteins is the key to understanding the behavior of the cytoskeleton and the cell as a whole. This proposal aims to examine issues relating to the structure, organization and function of the cytoskeleton. Specifically, we want to investigate the molecular interactions between various proteins involved in cell motility, as well as elucidate the factors that affect and control microtubule stability. These are complex systems that are difficult to study using single techniques. As such, we will be performing extensive computer simulation in collaboration with experimental colleagues in order to better understand the organization, interaction and dynamics of these important cellular structures.
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