This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rotaviruses are the leading etiologic agents of severe diarrheal disease in infants and young children, being responsible for an estimate of 600,000 annual deaths globally, and placing a significant economic burden on the global health care system. In this project we pretend to analyze the interactions that might occur between rotaviral proteins and yeast proteins. Many of the interactions that have been initially described in yeast have orthologues in mammalian cells. The two yeast hybrid system that is presently used in the YRC would allow us to look, in a genome-wide approach, for interaction partners of these rotaviral proteins.
Showing the most recent 10 out of 583 publications