The objective of the Hazard Identification Core is to provide toxicological and analytical services that will be utilized by virtually all of our Biomedical and Environmental Sciences Research Projects. This Core provides a number of services that many investigators require and that some investigators need, but are not technologically equipped to perform.
The Specific Aims of this Core are to provide research support in two areas: Biological Response and Metal Analysis. The Biological Response section will include ecotoxicity (bacterial and daphnia), mammalian cytotoxicity (HepG2 cells), and genotoxicity (Ames) assays. The daphnia - ecotoxicity analyses will be performed in a consortium agreement with the Dartmouth SBRP. The Metal Analyses section will use ICP-Mass Spectrometer analysis for total metal content and HPLC-ICP-MS for analysis of chemical species of metal. Multiple metals will be analyzed but the majority of the analyses will be for arsenic and its chemical species (e.g. metabolites). The Hazard Identification Core efficiently provides common analyses (biological or metal analyses) to our SBRP investigators thus allowing for more SBRP funds to be directed to the individual research projects as well as uniform quality control of the analyses.
|Pu, Mengjie; Guan, Zeyu; Ma, Yongwen et al. (2018) Synthesis of iron-based metal-organic framework MIL-53 as an efficient catalyst to activate persulfate for the degradation of Orange G in aqueous solution. Appl Catal A Gen 549:82-92|
|Brusseau, Mark L; Guo, Zhilin (2018) The integrated contaminant elution and tracer test toolkit, ICET3, for improved characterization of mass transfer, attenuation, and mass removal. J Contam Hydrol 208:17-26|
|Valentín-Vargas, Alexis; Neilson, Julia W; Root, Robert A et al. (2018) Treatment impacts on temporal microbial community dynamics during phytostabilization of acid-generating mine tailings in semiarid regions. Sci Total Environ 618:357-368|
|Brusseau, Mark L (2018) Assessing the potential contributions of additional retention processes to PFAS retardation in the subsurface. Sci Total Environ 613-614:176-185|
|Delikhoon, Mahdieh; Fazlzadeh, Mehdi; Sorooshian, Armin et al. (2018) Characteristics and health effects of formaldehyde and acetaldehyde in an urban area in Iran. Environ Pollut 242:938-951|
|Hammond, Corin M; Root, Robert A; Maier, Raina M et al. (2018) Mechanisms of Arsenic Sequestration by Prosopis juliflora during the Phytostabilization of Metalliferous Mine Tailings. Environ Sci Technol 52:1156-1164|
|Yan, Ni; Zhong, Hua; Brusseau, Mark L (2018) The natural activation ability of subsurface media to promote in-situ chemical oxidation of 1,4-dioxane. Water Res 149:386-393|
|Madeira, Camila L; Field, Jim A; Simonich, Michael T et al. (2018) Ecotoxicity of the insensitive munitions compound 3-nitro-1,2,4-triazol-5-one (NTO) and its reduced metabolite 3-amino-1,2,4-triazol-5-one (ATO). J Hazard Mater 343:340-346|
|Liu, Pengfei; Rojo de la Vega, Montserrat; Sammani, Saad et al. (2018) RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression. Proc Natl Acad Sci U S A 115:E10352-E10361|
|Thomas, Andrew N; Root, Robert A; Lantz, R Clark et al. (2018) Oxidative weathering decreases bioaccessibility of toxic metal(loid)s in PM10 emissions from sulfide mine tailings. Geohealth 2:118-138|
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