Abstract

The objective of the Hazard Identification Core is to provide toxicological and analytical services that will be utilized by virtually all of our Biomedical and Environmental Sciences Research Projects. This Core provides a number of services that many investigators require and that some investigators need, but are not technologically equipped to perform.
The Specific Aims of this Core are to provide research support in two areas: Biological Response and Metal Analysis. The Biological Response section will include ecotoxicity (bacterial and daphnia), mammalian cytotoxicity (HepG2 cells), and genotoxicity (Ames) assays. The daphnia - ecotoxicity analyses will be performed in a consortium agreement with the Dartmouth SBRP. The Metal Analyses section will use ICP-Mass Spectrometer analysis for total metal content and HPLC-ICP-MS for analysis of chemical species of metal. Multiple metals will be analyzed but the majority of the analyses will be for arsenic and its chemical species (e.g. metabolites). The Hazard Identification Core efficiently provides common analyses (biological or metal analyses) to our SBRP investigators thus allowing for more SBRP funds to be directed to the individual research projects as well as uniform quality control of the analyses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES004940-19
Application #
7599084
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
19
Fiscal Year
2008
Total Cost
$256,574
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Delikhoon, Mahdieh; Fazlzadeh, Mehdi; Sorooshian, Armin et al. (2018) Characteristics and health effects of formaldehyde and acetaldehyde in an urban area in Iran. Environ Pollut 242:938-951
Hammond, Corin M; Root, Robert A; Maier, Raina M et al. (2018) Mechanisms of Arsenic Sequestration by Prosopis juliflora during the Phytostabilization of Metalliferous Mine Tailings. Environ Sci Technol 52:1156-1164
Yan, Ni; Zhong, Hua; Brusseau, Mark L (2018) The natural activation ability of subsurface media to promote in-situ chemical oxidation of 1,4-dioxane. Water Res 149:386-393
Madeira, Camila L; Field, Jim A; Simonich, Michael T et al. (2018) Ecotoxicity of the insensitive munitions compound 3-nitro-1,2,4-triazol-5-one (NTO) and its reduced metabolite 3-amino-1,2,4-triazol-5-one (ATO). J Hazard Mater 343:340-346
Liu, Pengfei; Rojo de la Vega, Montserrat; Sammani, Saad et al. (2018) RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression. Proc Natl Acad Sci U S A 115:E10352-E10361
Thomas, Andrew N; Root, Robert A; Lantz, R Clark et al. (2018) Oxidative weathering decreases bioaccessibility of toxic metal(loid)s in PM10 emissions from sulfide mine tailings. Geohealth 2:118-138
Yan, Ni; Liu, Fei; Liu, Boyang et al. (2018) Treatment of 1,4-dioxane and trichloroethene co-contamination by an activated binary persulfate-peroxide oxidation process. Environ Sci Pollut Res Int :
Dehghani, Mansooreh; Sorooshian, Armin; Nazmara, Shahrokh et al. (2018) Concentration and type of bioaerosols before and after conventional disinfection and sterilization procedures inside hospital operating rooms. Ecotoxicol Environ Saf 164:277-282
Keshavarzi, Behnam; Abbasi, Sajjad; Moore, Farid et al. (2018) Contamination Level, Source Identification and Risk Assessment of Potentially Toxic Elements (PTEs) and Polycyclic Aromatic Hydrocarbons (PAHs) in Street Dust of an Important Commercial Center in Iran. Environ Manage 62:803-818
Dodson, Matthew; de la Vega, Montserrat Rojo; Harder, Bryan et al. (2018) Low-level arsenic causes proteotoxic stress and not oxidative stress. Toxicol Appl Pharmacol 341:106-113

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