The long-term goal of Project #4 is to better understand the relationship between the observed concentrations in ambient air and specific sources of airborne PCBs in residential and industrial communities. The central hypothesis is that emissions of airborne PCBs are a function of measureable and quantifiable characteristics of the physical-chemical characteristics of the compounds and exposed environmental surfaces on which the PCBs reside.
The Aims focus on identification, characterization and prediction of the magnitude and impact of sources of airborne PCBs:
Aim 1 : To determine the sources and fate of airborne PCB congeners in the urban/industrial complex of Chicago. We hypothesize that airborne PCBs in Chicago originate from contaminated surfaces throughout the city. We will test our hypotheses by deploying air samplers throughout the City of Chicago and over seasons. Using the measurements, models, and geographic databases, we will determine the relative contribution of Chicago sources toward the annual mass of PCBs deposited in Lake Michigan, distinguish long range versus local sources of airborne PCBs to the region, and determine neighborhoods of elevated risk for high exposure to airborne PCBs.
Aim 2 : To chapacterize the sources and Aroclor PCBs. We hypothesize that non-Aroclor PCBs have beeN released to the environment for decades and conthnue to be released due to their presence in commercial paint and other buil$ing materials. We wihl test this hypothesis by measuring non-Aroclor PCBs in archival and new samples and by measuring PCBs in c/mmercial paint. Using sediment cores and archived sample extracts, we will ddtermine the chronology of environmental exposure to these compounds and the magnitude of their current emissions.
Aim 3 : To characterize the emission and fate of airborne PCBs in the Indiana Harbor and Ship Canal (IHSC). We hypothesize that the sediment of the IHSC is a major source of airborne PCB congeners to the community of East Chicago, Indiana. To test our hypotheses, we will measure PCBs in deep sediments of the IHSC. We will calculate the release of PCBs under no-dredging and dredging-conditions, including partial Removal that exposes deep sediments. We will monitor the effect of dredging through local and regional air measurements. As a result of the work described here, Project #4 will promote more scientifically-sound and effective action to reduce human exposure to these potentially harmful compounds.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-LWJ-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Iowa
Iowa City
United States
Zip Code
Klaren, William D; Vine, David; Vogt, Stefan et al. (2018) Spatial distribution of metals within the liver acinus and their perturbation by PCB126. Environ Sci Pollut Res Int 25:16427-16433
Tomsho, Kathryn S; Basra, Komal; Rubin, Staci M et al. (2018) Correction to: Community reporting of ambient air polychlorinated biphenyl concentrations near a Superfund site. Environ Sci Pollut Res Int 25:16401
Uwimana, Eric; Li, Xueshu; Lehmler, Hans-Joachim (2018) Human Liver Microsomes Atropselectively Metabolize 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite. Environ Sci Technol 52:6000-6008
Herkert, Nicholas J; Hornbuckle, Keri C (2018) Effects of room airflow on accurate determination of PUF-PAS sampling rates in the indoor environment. Environ Sci Process Impacts 20:757-766
Herkert, Nicholas J; Spak, Scott N; Smith, Austen et al. (2018) Calibration and evaluation of PUF-PAS sampling rates across the Global Atmospheric Passive Sampling (GAPS) network. Environ Sci Process Impacts 20:210-219
Dhakal, Kiran; Gadupudi, Gopi S; Lehmler, Hans-Joachim et al. (2018) Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int 25:16277-16290
Enayah, Sabah H; Vanle, Brigitte C; Fuortes, Laurence J et al. (2018) PCB95 and PCB153 change dopamine levels and turn-over in PC12 cells. Toxicology 394:93-101
Klinefelter, Kelsey; Hooven, Molly Kromme; Bates, Chloe et al. (2018) Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mamm Genome 29:112-127
Gourronc, Francoise A; Robertson, Larry W; Klingelhutz, Aloysius J (2018) A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environ Sci Pollut Res Int 25:16481-16492
Alam, Sinthia; Carter, Gwendolyn S; Krager, Kimberly J et al. (2018) PCB11 Metabolite, 3,3'-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3: Examining the Contribution of MnSOD. Antioxidants (Basel) 7:

Showing the most recent 10 out of 298 publications