Abstract

CORE D: NPTMT ABSTRACT The Neuropathology and Targeted Molecular Testing (NPTMT) Core has been a valuable and frequently utilized resource for UW ADRC as it pursues its vision of precision medicine for Alzheimer's disease (AD) as well as for local and national AD research. The mission and thus, specific aims, have not significantly changed from the current award: (i) provide diagnostic expertise, (ii) provide targeted biomarker and genetic testing, (iii) build a highly accessible repository of brain tissue and fluid, (iv) develop innovative approaches, and (v) maintain a rich training environment. All of our research activities are focused on enhancing the research value of tissue and body fluid donations from cognitively healthy individuals and those in the early stages of AD while ensuring proper safeguards.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005136-33
Application #
9088283
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2016-05-01
Budget End
2017-04-30
Support Year
33
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Bagi, Zsolt; Brandner, Dieter D; Le, Phuong et al. (2018) Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter. Ann Neurol 83:142-152
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487
Keene, C Dirk; Wilson, Angela M; Kilgore, Mitchell D et al. (2018) Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Lab Invest :
Locke, Timothy M; Soden, Marta E; Miller, Samara M et al. (2018) Dopamine D1 Receptor-Positive Neurons in the Lateral Nucleus of the Cerebellum Contribute to Cognitive Behavior. Biol Psychiatry 84:401-412
Edlow, Brian L; Keene, C Dirk; Perl, Daniel P et al. (2018) Multimodal Characterization of the Late Effects of Traumatic Brain Injury: A Methodological Overview of the Late Effects of Traumatic Brain Injury Project. J Neurotrauma 35:1604-1619
Flanagan, Margaret E; Cholerton, Brenna; Latimer, Caitlin S et al. (2018) TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study. J Alzheimers Dis 66:1549-1558

Showing the most recent 10 out of 753 publications